A New Insight on Feasibility of Pre-, Pro-, and Synbiotics-based Therapies in Alzheimer’s Disease

Marjan Talebi; Vida Ebrahimi; Ahmadreza Rasouli; Afsaneh Farjami; Saiedeh Razi-Soofiyani; Alireza Soleimanian; Haleh Forouhandeh; Vahideh Tarhriz

doi:10.4103/jrptps.JRPTPS_170_21

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https://doi.org/10.4103/jrptps.JRPTPS_170_21

A New Insight on Feasibility of Pre-, Pro-, and Synbiotics-based Therapies in Alzheimer’s Disease

Author(s):

Marjan Talebi

¹,

Vida Ebrahimi

^2,*,

Ahmadreza Rasouli

^{3, 4},

Afsaneh Farjami^{5, 6},

Saiedeh Razi-Soofiyani

^{7, 8},

Alireza Soleimanian⁶,

Haleh Forouhandeh⁹,

Vahideh Tarhriz

⁸

1Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Department of Pharmaceutical Biotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Department of Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran

4Student Research Committee, School of Health, Qazvin, University of Medical Sciences, Qazvin, Iran

5Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

6Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

7Clinical Research Development Unit, Sina Educational, Research and Treatment Center, Tabriz University of Medical Sciences, Tabriz, Iran

8Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

9Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 11, issue 2; 141-55

Published online:Dec 23, 2022

Article type:Research Article

Received:Dec 05, 2021

Accepted:May 21, 2022

How to Cite:Marjan TalebiVida EbrahimiAhmadreza RasouliAfsaneh FarjamiSaiedeh Razi-SoofiyaniAlireza SoleimanianHaleh ForouhandehVahideh Tarhrizet al.A New Insight on Feasibility of Pre-, Pro-, and Synbiotics-based Therapies in Alzheimer’s Disease.J Rep Pharm Sci.11(2):e146232.https://doi.org/10.4103/jrptps.JRPTPS_170_21.

Abstract

Alzheimer’s disease is a prevalent cause of dementia in the elderly population. The existing treatments in this issue are limited in efficacy besides having several adverse effects. Therefore, developing new therapeutic strategies is a major concern of scientists. This disease is closely linked to gut microflora through the brain–gut–microbiota axis. Targeting gut microbiota by pre-, pro-, and synbiotics supplementation can be effective for its treatment. Herein, we discuss the protecting effects of pre-, pro-, and synbiotics products against Alzheimer’s disease based on comprehensive assessment of animal studies and performed clinical trials. Primarily, we briefly introduced involved pathogenesis, probable drug targets, and its correlation with gut microbiota. Subsequently, we debated preclinical and clinical research studies on the effect of pre-, pro-, and synbiotics agents on brain functionality, metabolic features, and biomarkers that are proven to have therapeutic effects. Searching the online databases revealed therapeutic capabilities of pre-, pro-, and synbiotics in Alzheimer’s disease treatment by some mechanisms such as anti-oxidative stress, anti-inflammatory, prohibiting of apoptosis and DNA damage, insulin regulation, suppressing the aggregation of beta-amyloid (Aβ) and tau proteins, which can be considered as important outcomes of this application.

Keywords

Alzheimer’s disease

brain–gut–microbiota axis

memory impairment probiotic

neurodegenerative disease

prebiotic

synbiotic

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Author(s):

Marjan Talebi:[PubMed][Scholar]
Vida Ebrahimi:[PubMed][Scholar]
Ahmadreza Rasouli:[PubMed][Scholar]
Afsaneh Farjami:[PubMed][Scholar]
Saiedeh Razi-Soofiyani:[PubMed][Scholar]
Alireza Soleimanian:[PubMed][Scholar]
Haleh Forouhandeh:[PubMed][Scholar]
Vahideh Tarhriz:[PubMed][Scholar]