Solid SMEDDS: An Approach for Dissolution Rate Enhancement Using Telmisartan as Model Drug

Ashish Pawar; Yogesh S Harak; Santosh R Tambe; Swati Talele; Deepak D Sonawane; Deelip V Derle

doi:10.4103/jrptps.JRPTPS_6_20

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https://doi.org/10.4103/jrptps.JRPTPS_6_20

Solid SMEDDS: An Approach for Dissolution Rate Enhancement Using Telmisartan as Model Drug

Author(s):

Ashish Pawar^1,*,

Yogesh S Harak¹,

Santosh R Tambe¹,

Swati Talele²,

Deepak D Sonawane³,

Deelip V Derle⁴

1Department of Pharmaceutics, MGV'S Pharmacy College, Nashik, Maharashtra, India

2Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra, India

3Department of Pharmaceutics, Divine College of Pharmacy, Nashik, Maharashtra, India

4Department of Pharmaceutics, MVP's College of Pharmacy, Nashik, Maharashtra, India

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 2; 198-208

Published online:Dec 17, 2021

Article type:Research Article

Received:Feb 26, 2021

Accepted:Oct 16, 2021

How to Cite:Ashish PawarYogesh S HarakSantosh R TambeSwati TaleleDeepak D SonawaneDeelip V Derleet al.Solid SMEDDS: An Approach for Dissolution Rate Enhancement Using Telmisartan as Model Drug.J Rep Pharm Sci.10(2):e146881.https://doi.org/10.4103/jrptps.JRPTPS_6_20.

Abstract

Bioavailability improvement of poorly water-soluble drugs is a challenging task for many of the drug candidates. In recent years, an area that is ahead in popularity for different formulation expertise is the use of lipid-based careers to formulate self-emulsifying drug delivery systems (SEDDS) for enhancing the oral bioavailability of lipophilic drugs. The self-microemulsifying drug delivery systems (SMEDDS) are thermodynamically stable and isotropic solutions containing an oil, surfactant, co-surfactant (CoS; or solubilizer), and mixtures of drug which forms oil-in-water microemulsions when incorporated in water and stirred. Different techniques are available to convert liquid–self-microemulsifying drug delivery systems (L-SMEDDS) to solid among which an adsorption technique is economical and very simple. The solid– self-microemulsifying drug delivery systems (S-SMEDDS) of telmisartan (TEL) was developed in the present study which is a poorly water-soluble drug. Different formulations of L-SMEDDS were developed using Capmul PG 8 as oil, Cremophor RH 40 as a surfactant, and Transcutol P as a CoS and were later transformed to S-SMEDDS. The formulations were assessed for dilution study by visual observation, differential scanning calorimetry, analysis of solid S-SMEDDS morphologically, in vitro dissolution test, zeta potential measurement, etc. Significantly higher drug release was observed from S-SMEDDS as compared to plain TEL. Hence, it can be concluded that the adsorption technique is a promising approach for the formulation of S-SMEDDS with improved dissolution rate and concomitantly bioavailability.

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Author(s):

Ashish Pawar:[PubMed][Scholar]
Yogesh S Harak:[PubMed][Scholar]
Santosh R Tambe:[PubMed][Scholar]
Swati Talele:[PubMed][Scholar]
Deepak D Sonawane:[PubMed][Scholar]
Deelip V Derle:[PubMed][Scholar]