Hepatoprotective Effects of Hertia cheirifolia Butanolic Extract and Selenium against CCl4 -induced Toxicity in Rats

Mouna Menakh Menakh; Saber Boutellaa; Djahida Mahdi; Amar Zellagui; Mesbah Lahouel; Mehmet &Ouml;zt&uuml;rk

doi:10.4103/jrptps.JRPTPS_25_20

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https://doi.org/10.4103/jrptps.JRPTPS_25_20

Hepatoprotective Effects of Hertia cheirifolia Butanolic Extract and Selenium against CCl4 -induced Toxicity in Rats

Author(s):

Mouna Menakh Menakh^1,*,

Saber Boutellaa^{2, 3},

Djahida Mahdi^{1, 4},

Amar Zellagui²,

Mesbah Lahouel⁵,

Mehmet Öztürk⁶

1Department of Nature and Life Sciences, Faculty of Exact Sciences and Nature and Life Sciences, Oum El Bouaghi University, Oum El Bouaghi, Algeria

2Laboratory of Bio-molecules and Plant Breeding, Department of Nature and Life Sciences, Faculty of Exact Sciences, Oum El Bouaghi University, Oum El Bouaghi, Algeria

3Department of Nature and Life Sciences, University Center Abdehafid Boussouf, Mila, Algeria

4Laboratory of Animal Eco-Physiology, Department of Biology, Faculty of Sciences, Badji Mokhtar University, Annaba, Algeria

5Laboratory of Molecular Toxicology, Faculty of Sciences, Jijel University, Jijel, Algeria

6Department of Chemistry, Faculty of Sciences, Muğla Sıtkı Koçman University, Mugla, Turkey

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 2; 216-24

Published online:Dec 17, 2021

Article type:Research Article

Received:Apr 05, 2020

Accepted:Oct 16, 2021

How to Cite:Mouna Menakh MenakhSaber BoutellaaDjahida MahdiAmar ZellaguiMesbah LahouelMehmet Öztürket al.Hepatoprotective Effects of Hertia cheirifolia Butanolic Extract and Selenium against CCl4 -induced Toxicity in Rats.J Rep Pharm Sci.10(2):e146885.https://doi.org/10.4103/jrptps.JRPTPS_25_20.

Abstract

Background: Hertia cheirifolia, a traditional plant endemic to both Tunisia and Algeria, is used for the treatment of various disorders. This study investigates the antioxidant and protective effects of H. cheirifolia butanolic extract (BEHC) alone and combined with selenium (Se) against carbon tetrachloride (CCl4)- induced liver damage in rats.
Experimental Procedure: Thirty male Wistar rats were randomly divided into six groups: (1) normal control, (2) hepatotoxic control, (3) positive control received silymarin 100 mg/ kg body weight (bw), (4) BEHC (100 mg/kg bw), (5) BEHC (400 mg/kg bw), and (6) BEHC (400 mg/kg bw) + Se (0,3 mg/kg bw) once daily for 14 consecutive days, followed by hepatotoxicity induction with CCl4 in olive oil 0.6 mL/kg bw intraperitoneally. Some biochemical and oxidative stress parameters were investigated. Quantity and quality of phenolics in BEHC were determined by spectrophotometer and high-performance liquid chromatography with diode-array detection (HPLC-DAD) analysis, respectively.
Results and Conclusion: BEHC contained high amounts of total phenolics and flavonoids where seven compounds were identified. The pretreatment with BEHC or with BEHC and Se significantly reduced the levels of plasma aminotransferases (alanine aminotransferase [AST] and aspartate aminotransferase [ALT]), alkaline phosphatase, malondialdehyde (MDA), and increasing glutathione (GSH), catalase (CAT), and superoxide dismutase (SOD) levels in hepatic tissues. In conclusion, BEHC has a potent natural antioxidant activity that can be used with Se to reduce hepatotoxicity.

Keywords

Carbon tetrachloride

hepatotoxicity in rat

Hertia cheirifolia

oxidative stress

selenium

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Author(s):

Mouna Menakh Menakh:[PubMed][Scholar]
Saber Boutellaa:[PubMed][Scholar]
Djahida Mahdi:[PubMed][Scholar]
Amar Zellagui:[PubMed][Scholar]
Mesbah Lahouel:[PubMed][Scholar]
Mehmet Öztürk:[PubMed][Scholar]