The Randomized Clinical Trial of Safety and Efficacy of Oral Tramadol in Patients Undergoing Colonoscopy

Mehdi Zobeiri; Teimour Kamari; Mansour Rezaei; MohammadHossein Farzaei

doi:10.4103/jrptps.JRPTPS_9_21

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https://doi.org/10.4103/jrptps.JRPTPS_9_21

The Randomized Clinical Trial of Safety and Efficacy of Oral Tramadol in Patients Undergoing Colonoscopy

Author(s):

Mehdi Zobeiri

¹,

Teimour Kamari¹,

Mansour Rezaei²,

MohammadHossein Farzaei

^3,*

1Department of Internal Medicine, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 2; 261-4

Published online:Dec 17, 2021

Article type:Research Article

Received:Jan 20, 2021

Accepted:Apr 12, 2021

How to Cite:Mehdi ZobeiriTeimour KamariMansour RezaeiMohammadHossein FarzaeiThe Randomized Clinical Trial of Safety and Efficacy of Oral Tramadol in Patients Undergoing Colonoscopy.J Rep Pharm Sci.10(2):e146962.https://doi.org/10.4103/jrptps.JRPTPS_9_21.

Abstract

Background and Study Aims: Colonoscopy is a wide-spreading procedure with pain as a habitual challenge for the therapeutic team. The aim of this study is to evaluate safety and efficacy of oral tramadol in patients undergoing colonoscopy.
Patients and Methods: This randomized controlled trial was performed in 124 consecutive patients who completed total colonoscopy, which is randomly divided into two groups, receiving either 100 mg single dose oral tramadol or placebo. Pain intensity during colonoscopy is evaluated by numerical rating scale (NRS) criteria in four levels: no pain, mild, moderate, and severe pain. This study was registered in www.IRCT.ir, number: IRCT2015010820610N1.
Results: Two groups were matched in age, sex, and colonoscopy indication. The pain intensity in patients receiving tramadol was significantly lower than that in patients receiving placebo (P <0.05). Nausea, sweating, moaning, and palpitation during colonoscopy were significantly lower, and desire to do a colonoscopy without sedation was significantly higher in the tramadol group.
Conclusion: Oral tramadol in patients undergoing colonoscopy is effective in reducing pain and symptoms.

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Author(s):

Mehdi Zobeiri:[PubMed][Scholar]
Teimour Kamari:[PubMed][Scholar]
Mansour Rezaei:[PubMed][Scholar]
MohammadHossein Farzaei:[PubMed][Scholar]