Attenuation of Hyperinsulinemia-induced DNA Damage of Peripheral Lymphocytes by Carvedilol

Farshad Naghsh; Mahmoud Etebari

doi:10.4103/jrptps.JRPTPS_1_21

Outlines

Abstract
Copyright

https://doi.org/10.4103/jrptps.JRPTPS_1_21

Attenuation of Hyperinsulinemia-induced DNA Damage of Peripheral Lymphocytes by Carvedilol

Author(s):

Farshad Naghsh¹,

Mahmoud Etebari^2,*

1Department of Pharmacology and Toxicology, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2Department of Pharmacology and Toxicology, and Isfahan Pharmaceutical Sciences Research Center, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 2; 265-70

Published online:Dec 17, 2021

Article type:Research Article

Received:Jan 03, 2021

Accepted:Jul 24, 2021

How to Cite:Farshad NaghshMahmoud EtebariAttenuation of Hyperinsulinemia-induced DNA Damage of Peripheral Lymphocytes by Carvedilol.J Rep Pharm Sci.10(2):e146963.https://doi.org/10.4103/jrptps.JRPTPS_1_21.

Abstract

Context: Most people with diabetes suffer from cardiovascular problems; however, increased oxidative stress caused by diabetes can increase the risk of DNA damage and cancer. Carvedilol is a third-generation beta-blocker that can both improve heart function and prevent oxidative stress.
Aims: The present study aimed to assess carvedilol’s genoprotective effects against hyperinsulinemia-induced DNA strand break in rats.
Materials and Methods: To evaluate the extent of DNA damage caused by high insulin concentrations and the effect of carvedilol on these lesions, isolated lymphocytes of high-fat type 2 diabetic rats were evaluated using the comet method.
Results: Our results in this study using the comet method showed that hyperinsulinemia and hyperglycemia of high-fat diet have significant genotoxic parameters in rats (tail length 84.35 ± 0.23 vs. 0.90 ± 0.02, % DNA in tail 16.09 ± 0.09 vs. 7.63 ± 0.04, and tail moment 13.58 ± 0.09 vs. 0.07 ± 0.01) compared with the control group (P < 0.001). In rats receiving carvedilol, we observed the genoprotective effect in a dose-dependent manner, which is predicted due to the antioxidant activity of carvedilol and its metabolites.
Conclusion: It does not have an adverse effect on the blood sugar profile of diabetics and reduction of cardiovascular complications of the disease; carvedilol can prevent genetic damage and cancer risk in hyperinsulinemia induced by the high-fat diet.

Keywords

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Farshad Naghsh:[PubMed][Scholar]
Mahmoud Etebari:[PubMed][Scholar]