Evaluation of the Matrix-forming Ability of Chrysophyllum albidum Linn Fruit Gum in Sustained-release Tablet Formulations

Ephraim Esla; Olubunmi Olayemi; Babah A Isah; Susan T Allagh

doi:10.4103/jrptps.JRPTPS_13_20

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https://doi.org/10.4103/jrptps.JRPTPS_13_20

Evaluation of the Matrix-forming Ability of Chrysophyllum albidum Linn Fruit Gum in Sustained-release Tablet Formulations

Author(s):

Ephraim Esla¹,

Olubunmi Olayemi^2,*,

Babah A Isah¹,

Susan T Allagh¹

1Department of Pharmaceutics and Pharmaceutical Technology, Ahmadu Bello University, Zaria, Nigeria

2Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development (NIPRD), Idu Industrial Area, Abuja, Nigeria

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 1; 5-14

Published online:May 31, 2021

Article type:Research Article

Received:Feb 25, 2020

Accepted:Mar 30, 2021

How to Cite:Ephraim EslaOlubunmi OlayemiBabah A IsahSusan T AllaghEvaluation of the Matrix-forming Ability of Chrysophyllum albidum Linn Fruit Gum in Sustained-release Tablet Formulations.J Rep Pharm Sci.10(1):e146974.https://doi.org/10.4103/jrptps.JRPTPS_13_20.

Abstract

Background and Purpose: Muscari Miller. (Asparagaceae family) contains about 50 species worldwide, which are distributed in the Central and Southeastern Europe, Southern Russia, Africa, and some area of Asia such as Iran, Iraq, Afghanistan, Anatolia, and Syria. This study was designed to assess the antioxidant and antimalarial activities of Muscari inconstrictum Rech. f. seeds as one of the Iranian species of Muscari genus. In addition, preliminary phytochemical analysis of the extracts with different polarities was performed.
Materials and Methods: The essential oil of M. inconstrictum seeds was prepared using Clevenger and extracted with n-hexane, chloroform, and methanol (MeOH) by Soxhlet apparatus. Gas chromatography-mass spectrometry (GC-MS) was used for the characterization of essential oil. Total phenol and flavonoid contents were measured using Folin–Ciocalteu and aluminum chloride reagents. Free radical scavenging and antimalarial activities were investigated via 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and cell-free ß-hematin formation methods.
Results: GC-MS analysis of the volatile oil of seeds demonstrated the presence of sesquiterpenoid, alkanes, fatty acid, and linear alcohol structures as the main constituents. Among different extracts of M. inconstrictum seeds, the methanolic extract showed significant antioxidant activity, which can be related to the presence of flavonoid and other phenolic structures. Furthermore, chloroform extract is introduced as the most potent antimalarial part.
Conclusion: It seems that further studies on the M. inconstrictum seeds are necessary to focus on pure compounds and their biological activities.

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Author(s):

Ephraim Esla:[PubMed][Scholar]
Olubunmi Olayemi:[PubMed][Scholar]
Babah A Isah:[PubMed][Scholar]
Susan T Allagh:[PubMed][Scholar]