Anti-inflammatory Effects of Memantine in Carrageenan-induced Paw Edema Model in Rats

Mahtab Azarbaijani; Mehdi Kian; Hamid Soraya

doi:10.4103/jrptps.JRPTPS_37_20

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https://doi.org/10.4103/jrptps.JRPTPS_37_20

Anti-inflammatory Effects of Memantine in Carrageenan-induced Paw Edema Model in Rats

Author(s):

Mahtab Azarbaijani¹,

Mehdi Kian

²,

Hamid Soraya

^1,*

1Department of Pharmacology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran

2Department of Comparative Biomedical Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 1; 60-5

Published online:May 31, 2021

Article type:Research Article

Received:Apr 11, 2020

Accepted:Aug 30, 2020

How to Cite:Mahtab AzarbaijaniMehdi KianHamid SorayaAnti-inflammatory Effects of Memantine in Carrageenan-induced Paw Edema Model in Rats.J Rep Pharm Sci.10(1):e147089.https://doi.org/10.4103/jrptps.JRPTPS_37_20.

Abstract

Background: The anti-inflammatory effect of memantine (MEM) was investigated using carrageenaninduced hind paw edema model in rats.
Materials and Methods: Thirty male Wistar rats were randomly assigned to five groups (n = 6). Group 1 received 0.1 mL of 1% carrageenan at the right hind paw. Group 2 received dexamethasone (10 mg/kg) and Groups 3, 4, and 5 received 5, 10, and 20 mg/kg MEM intraperitoneally (ip), 20 min after injection of carrageenan into the right hind paw, respectively. Animals’ paw thickness was measured at 0, 1, 2, 3, 4, and 5 h after carrageenan injection. Then, animals were euthanized and myeloperoxidase (MPO) and malondialdehyde (MDA) levels were measured in the paw tissues. The tissue samples were further examined histopathologically using light microscopy. One-way ANOVA and Tukey post hoc test was used to compare the mean values between the groups.
Results: Treating with MEM at all doses significantly decreased hind paw thickness at 2 (P < 0.05 and P < 0.01 at MEM 10 mg/kg and MEM 5 and 20 mg/kg, respectively), 3 (P < 0.001), and 4 (P < 0.001 at 5 mg/kg and P < 0.01 at MEM 10 and 20 mg/kg) hours after carrageenan injection in comparison to the carrageenan group. There was a significant (P < 0.05 and P < 0.001, respectively) reduction in MPO activity and MDA levels in MEM-treated groups when compared with the carrageenan group.
Conclusion: This study showed that MEM decreased paw edema, leukocyte infiltration, MPO activity, and MDA levels,
and MEM can be considered as an effective anti-inflammatory agent.

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Author(s):

Mahtab Azarbaijani:[PubMed][Scholar]
Mehdi Kian:[PubMed][Scholar]
Hamid Soraya:[PubMed][Scholar]