Artocarpus altilis Leaf Extract Protects Pancreatic Islets and Improves Glycemic Control in Alloxan-induced Diabetic Rats

Yulia Djabir; Hardi Hardi; Hesty Setiawati; Subehan Lallo; Risfah Yulianty; M. Husni Cangara; Veni Hadju

doi:10.4103/jrptps.JRPTPS_57_20

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https://doi.org/10.4103/jrptps.JRPTPS_57_20

Artocarpus altilis Leaf Extract Protects Pancreatic Islets and Improves Glycemic Control in Alloxan-induced Diabetic Rats

Author(s):

Yulia Djabir^1,*,

Hardi Hardi²,

Hesty Setiawati²,

Subehan Lallo³,

Risfah Yulianty⁴,

M. Husni Cangara⁵,

Veni Hadju⁶

1Laboratory of Clinical Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia

2Postgraduate study program, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia

3Laboratory of Phytochemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia

4Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia

5Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia

6Department of Nutrition, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 1; 87-92

Published online:May 31, 2021

Article type:Research Article

Received:Mar 15, 2021

Accepted:Mar 30, 2021

How to Cite:Yulia DjabirHardi HardiHesty SetiawatiSubehan LalloRisfah YuliantyM. Husni CangaraVeni Hadjuet al.Artocarpus altilis Leaf Extract Protects Pancreatic Islets and Improves Glycemic Control in Alloxan-induced Diabetic Rats.J Rep Pharm Sci.10(1):e147094.https://doi.org/10.4103/jrptps.JRPTPS_57_20.

Abstract

The antioxidant capacity of Artocarpus altilis leaf extract may offer protection against stress oxidativeinduced damage to pancreatic cells. This study aimed to examine the effect of Artocarpus leaf extract on pancreatic islets structure, blood glucose (BG), and insulin serum levels in alloxan-induced diabetic rats. Diabetes mellitus was induced in rats with an intraperitoneal injection of alloxan (155 mg/kg). Rats’ BG levels were measured daily. Only rats with BG >250 mg/dL (n = 25) proceeded to receive different treatments: placebo, Artocarpus leaf extract at the dose of 100, 200, or 400 mg/kg, or insulin 6 IU/200 g. All treatments were administered daily for 14 days before blood and pancreatic tissue samples were collected. Five healthy rats (n = 5) were included to serve as normal controls. The result shows that alloxan-induced atrophy of pancreatic islets and Artocarpus leaf extract administration at all given doses reduced the severity of pancreatic islet’s atrophy. However, only at 400 mg/kg dose, Artocarpus leaf extract significantly reduced rats’ BG level (P < 0.05), similar to that of insulin-treated rats. Artocarpus leaf extract, especially at 100 and 400 mg/kg doses, also improved insulin serum levels compared with placebo treatment (P < 0.05). In conclusion, Artocarpus leaf extract protected rats’ pancreatic islets against alloxan-induced damage. This protection could improve the BG and insulin serum levels in Artocarpus-treated rats.

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Author(s):

Yulia Djabir:[PubMed][Scholar]
Hardi Hardi:[PubMed][Scholar]
Hesty Setiawati:[PubMed][Scholar]
Subehan Lallo:[PubMed][Scholar]
Risfah Yulianty:[PubMed][Scholar]
M. Husni Cangara:[PubMed][Scholar]
Veni Hadju:[PubMed][Scholar]