A Review on Solubility Enhancement Methods for Poorly Water-soluble Drugs

Ahmad Ainurofiq; David Sarono Putro; Dhea Aqila Ramadhani; Gemala Mahendra Putra; Laura Da Costa Do Espirito Santo

doi:10.4103/jrptps.JRPTPS_134_19

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https://doi.org/10.4103/jrptps.JRPTPS_134_19

A Review on Solubility Enhancement Methods for Poorly Water-soluble Drugs

Author(s):

Ahmad Ainurofiq^1,*,

David Sarono Putro¹,

Dhea Aqila Ramadhani¹,

Gemala Mahendra Putra¹,

Laura Da Costa Do Espirito Santo¹

1Department of Pharmacy, Sebelas Maret University, Ir. Sutami 36A, Surakarta, 57126, Indonesia

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 1; 137-47

Published online:May 31, 2021

Article type:Systematic Review

Received:Feb 08, 2020

Accepted:Aug 30, 2020

How to Cite:Ahmad AinurofiqDavid Sarono PutroDhea Aqila RamadhaniGemala Mahendra PutraLaura Da Costa Do Espirito SantoA Review on Solubility Enhancement Methods for Poorly Water-soluble Drugs.J Rep Pharm Sci.10(1):e147104.https://doi.org/10.4103/jrptps.JRPTPS_134_19.

Abstract

One of the most important parameters in pharmacy is drug solubility. Solubility affects the efficacy of
a drug. Drug solubility has an important role in determining the concentration of a drug to achieve the
necessary pharmacological response, as all drugs absorbed by the body must be in the form of a solution.
Drug solubility is quite a common issue and affects the bioavailability of a drug in the body. Drugs with
low solubility are poorly absorbed, resulting in poor bioavailability. Many methods have been developed
for increasing the solubility of a drug. In this review, we will describe possible efforts for improving the
solubility of a drug, e.g., reducing particle size, surfactants, the use of nanosuspension technology, solid
dispersion, salt formation, pH adjustment, hydrotropy, cocrystal, amorphous compound formation, and
inclusion complexes. The main objective of this review was to focus on efforts that can increase the
solubility of a drug to obtain good drug efficacy.

Keywords

Poor soluble drug

solubility

solubility enhancement method

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Author(s):

Ahmad Ainurofiq:[PubMed][Scholar]
David Sarono Putro:[PubMed][Scholar]
Dhea Aqila Ramadhani:[PubMed][Scholar]
Gemala Mahendra Putra:[PubMed][Scholar]
Laura Da Costa Do Espirito Santo:[PubMed][Scholar]