Comparative Antibacterial Study of Black Cumin Oil of Saudi and Syrian Origin Seeds with the Commercial Product

Mohammad Rashid; Majid A. Ganaie; Shamshir Khan; Naseem Akhtar; Makhmur Ahmad; Saiba Shams; Omer S. Hamid Bilal; Dheeraj Bisht

doi:10.4103/jrptps.JRPTPS_118_20

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https://doi.org/10.4103/jrptps.JRPTPS_118_20

Comparative Antibacterial Study of Black Cumin Oil of Saudi and Syrian Origin Seeds with the Commercial Product

Author(s):

Mohammad Rashid¹,

Majid A. Ganaie¹,

Shamshir Khan¹,

Naseem Akhtar¹,

Makhmur Ahmad^1,*,

Saiba Shams²,

Omer S. Hamid Bilal³,

Dheeraj Bisht⁴

1Department of Pharmaceutical Chemistry and Pharmacognosy, College of Dentistry and Pharmacy, Buraydah Colleges, Buraydah, Al-Qassim, Kingdom of Saudi Arabia

2Department of Pharmaceutics, School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh, India

3Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Buraydah Colleges, Buraydah, Al-Qassim, Kingdom of Saudi Arabia

4Department of Pharmaceutical Sciences, Sir J. C. Bose Technical Campus Bhimtal, Kumaun University, Nainital, Uttarakhand, India

Journal of Reports in Pharmaceutical Sciences:Vol. 10, issue 1; 148-52

Published online:May 31, 2021

Article type:Rapid Communication

Received:Sep 27, 2020

Accepted:Apr 07, 2021

How to Cite:Rashid M, Ganaie M A, Khan S, Akhtar N, Ahmad M, et al. Comparative Antibacterial Study of Black Cumin Oil of Saudi and Syrian Origin Seeds with the Commercial Product.J Rep Pharm Sci.2021;10(1):e147105.https://doi.org/10.4103/jrptps.JRPTPS_118_20.

Abstract

Background: A literature survey showed that significant work has been done to evaluate antimicrobial activity of medicinal plants and their constituents. Thousands of phytoconstituents are tested against a wide range of microbial strains in vitro, in vivo, and clinically. Black cumin oil obtained from the seeds of Nigella sativa L. is used as carminative, stimulant, diuretic, emmenagogue, lactagogue, and anthelmintic. Seed oil is applied externally on skin as antiseptic, emollient, and to prevent cold symptoms. Many studies have displayed the antimicrobial activity of black seed oil against a variety of microorganisms including Gram-positive and Gram-negative bacteria. In the present study, a comparative antibacterial activity of black cumin oil of Saudi Arabian, Syrian seeds, and marketed/branded oil was undertaken.
Materials and Methods: Black cumin oil (12%) is obtained from Saudi and Syrian originated seeds by the soxhlet extraction method. Agar disc diffusion method was applied for antibacterial activity of each oil and two marketed oils. Antibacterial activity of different black cumin oil samples has been evaluated against standard Escherichia coli, standard Klebsiella pneumonia, and standard Staphylococcus aureus. Phytochemical screening is also done to check the presence of phytoconstituents, which might be responsible for the activity.
Results: All black cumin oil samples are found to be sensitive to S. aureus only. Black cumin of Saudi originated seeds showed higher activity than Syrian. Seeds oil of Syria had almost similar activity to one of the marketed oils (M1). Another marketed black cumin oil (M2) showed highest antibacterial activity among all types of oils. Phytochemical screening of these oils showed the presence of steroids and alkaloids, which might be responsible for the activity. Several factors that affect the phytochemical variations are environmental, geographical, agricultural, and extraction conditions, which result in differences in their antibacterial activity.
Conclusion: The results of this study showed that all samples of black cumin oils have antibacterial activity against S. aureus (Gram-positive bacteria). Therefore, they might be considered as possible alternatives to antibiotics for the treatment of S. aureus infections.

Keywords

Agar disc diffusion method

antibacterial activity

black cumin (Nigella sativa) seed oil

photochemical screening

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Author(s):

Mohammad Rashid:[PubMed][Scholar]
Majid A. Ganaie:[PubMed][Scholar]
Shamshir Khan:[PubMed][Scholar]
Naseem Akhtar:[PubMed][Scholar]
Makhmur Ahmad:[PubMed][Scholar]
Saiba Shams:[PubMed][Scholar]
Omer S. Hamid Bilal:[PubMed][Scholar]
Dheeraj Bisht:[PubMed][Scholar]