Synthesis and Comparison of Anti-Leishmania major Activity of Antimony and Iron Complexes of 3-Hydroxypyran-4-One and 3-Hydroxypyridine-4- One as Bi-Dentate Ligands

Zeynab Zarrabi; Latfollah Saghaie; Afshin Fassihi; Nader Pestechian; Sedigheh Saberi

doi:10.4103/jrptps.JRPTPS_64_18

Outlines

Abstract
Copyright

https://doi.org/10.4103/jrptps.JRPTPS_64_18

Synthesis and Comparison of Anti-Leishmania major Activity of Antimony and Iron Complexes of 3-Hydroxypyran-4-One and 3-Hydroxypyridine-4- One as Bi-Dentate Ligands

Author(s):

Zeynab Zarrabi¹,

Latfollah Saghaie¹,

Afshin Fassihi¹,

Nader Pestechian²,

Sedigheh Saberi

^2,*

1Department of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2Department of Mycology and Parasitology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 9, issue 2; 177-82

Published online:Oct 07, 2020

Article type:Research Article

Received:Nov 24, 2018

Accepted:Dec 03, 2018

How to Cite:Zeynab ZarrabiLatfollah SaghaieAfshin FassihiNader PestechianSedigheh SaberiSynthesis and Comparison of Anti-Leishmania major Activity of Antimony and Iron Complexes of 3-Hydroxypyran-4-One and 3-Hydroxypyridine-4- One as Bi-Dentate Ligands.J Rep Pharm Sci.9(2):e147110.https://doi.org/10.4103/jrptps.JRPTPS_64_18.

Abstract

Background: Leishmaniasis infection threatens millions of people in under developing and developing countries. Treatment of this neglected disease is very complicated.
Subjects and Methods: A novel series of antimony (V) complexes using bidentate ligands of hydroxypyranones and hydroxypyridinones have been designed and synthesized. For the synthesis of the complexes, SbCl5 in water was added to the solution of each ligand at 60°C and the pH of mixture was adjusted to 8 using aqueous NaOH. After 24 h stirring, extraction of produced compound into acetone gave the desired complex. The structure of complexes was achieved by using FTIR, 1HNMR, and electron spin ionization mass spectroscopic techniques. All compounds were evaluated for in vitro anti amastogote form of Leishmania major.
Results and Conclusion: The most potent antimony complexes against amastigotes were 5b (after 48 and 72 h) and 5a (after 72 h) with IC50 values of 24.4, 16.3, and 30.1 μg/mL, respectively. Furthermore, antimony and iron complexes were used together for in vitro anti amastigote form of L. major activity. These compounds were toxic for macrophages and destroyed them.

Keywords

Anti-leishmania activity

antimony (V) complexes

iron complexes

Leishmania major

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Zeynab Zarrabi:[PubMed][Scholar]
Latfollah Saghaie:[PubMed][Scholar]
Afshin Fassihi:[PubMed][Scholar]
Nader Pestechian:[PubMed][Scholar]
Sedigheh Saberi:[PubMed][Scholar]