Repeated Administration of Fluvoxamine Worsens Gentamicin-induced Nephrotoxicity in Rats

Afshin Ramian; Iraj Javadi; Hossein Sadeghi; Heibatollah Sadeghi; Esmaeel Panahi Kokhdan; Amir Hossein Doustimotlagh; Reza Abbasi; Sadegh Alizadeh; Hamed Nikbakht

doi:10.4103/jrptps.JRPTPS_57_19

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https://doi.org/10.4103/jrptps.JRPTPS_57_19

Repeated Administration of Fluvoxamine Worsens Gentamicin-induced Nephrotoxicity in Rats

Author(s):

Afshin Ramian¹,

Iraj Javadi¹,

Hossein Sadeghi^{2, 3,*},

Heibatollah Sadeghi^{2, 3},

Esmaeel Panahi Kokhdan²,

Amir Hossein Doustimotlagh²,

Reza Abbasi²,

Sadegh Alizadeh¹,

Hamed Nikbakht¹

1Departemant of Toxicology, Shahreza Branch, Islamic Azad University, Shahreza, Iran

2Medicinal Plants Research Center, Yasuj University of Medical Sciences, Yasuj, Iran

3Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 9, issue 2; 196-202

Published online:Oct 07, 2020

Article type:Research Article

Received:Oct 20, 2019

Accepted:May 19, 2020

How to Cite:Afshin RamianIraj JavadiHossein SadeghiHeibatollah SadeghiEsmaeel Panahi KokhdanAmir Hossein DoustimotlaghReza AbbasiSadegh AlizadehHamed Nikbakhtet al.Repeated Administration of Fluvoxamine Worsens Gentamicin-induced Nephrotoxicity in Rats.J Rep Pharm Sci.9(2):e147113.https://doi.org/10.4103/jrptps.JRPTPS_57_19.

Abstract

Background: Depression is one of the most prevalent and life-threatening forms of mental disorders in chronic kidney disease. Antidepressant agents such as fluvoxamine are broadly prescribed in this situation. This study investigated the effects of fluvoxamine on gentamicin (GEN)-induced nephrotoxicity in rats.
Materials and Methods: Twenty-four male Wistar rats were randomly divided into four groups (n = 6) including (1) control group, (2) GEN group, (3) GEN + fluvoxamine (25 mg/kg) group, and (4) GEN + fluvoxamine (50 mg/kg) group. Fluvoxamine was orally given to animals 45 min before GEN was injected (100 mg/kg, intraperitoneally [i.p.]). Blood urea nitrogen (BUN), creatinine (Cr), sodium (Na+), potassium (K+), and malondialdehyde (MDA) levels in serum were measured. Moreover, the glucose (Glu) and protein (Pro) levels in urine and the ratio of kidney to body weight (g/100 g body weight) were determined. Histopathological alterations in kidney were evaluated.
Results: GEN significantly increased the Cr and BUN serum levels as well as urine Glu and Pro concentrations (P ≤ 0.001). Fluvoxamine exacerbated the elevation in the indicated parameters. GEN also significantly increased the serum MDA levels. Fluvoxamine had no effect on the elevated serum levels of MDA. GEN did not show any effect on the K+ and Na+ serum concentrations. Increased kidney-to-body weight ratio due to GEN nephrotoxicity was further exacerbated by 25 mg/kg of fluvoxamine (P ≤ 0.001). Pathologic findings also confirm the biochemical results.
Conclusion: The data suggest that fluvoxamine worsens the nephrotoxicity of GEN. However, further clinical and animal investigations are required to elucidate the mechanism of this interaction.

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Author(s):

Afshin Ramian:[PubMed][Scholar]
Iraj Javadi:[PubMed][Scholar]
Hossein Sadeghi:[PubMed][Scholar]
Heibatollah Sadeghi:[PubMed][Scholar]
Esmaeel Panahi Kokhdan:[PubMed][Scholar]
Amir Hossein Doustimotlagh:[PubMed][Scholar]
Reza Abbasi:[PubMed][Scholar]
Sadegh Alizadeh:[PubMed][Scholar]
Hamed Nikbakht:[PubMed][Scholar]