Recent Advances in the Development of the Nanostructured Lipid Carriers for the Topical Fungal Infections

Amandeep -; Shailendra Bhatt; Manish Kumar; Sheetal Devi; Prabhat Kumar Upadhyay; Vipin Saini; Amit Mittal; Navneet Mehan; Anupam Saini

doi:10.4103/jrptps.JRPTPS_99_19

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https://doi.org/10.4103/jrptps.JRPTPS_99_19

Recent Advances in the Development of the Nanostructured Lipid Carriers for the Topical Fungal Infections

Author(s):

Amandeep -¹,

Shailendra Bhatt¹,

Manish Kumar^1,*,

Sheetal Devi¹,

Prabhat Kumar Upadhyay²,

Vipin Saini³,

Amit Mittal³,

Navneet Mehan¹,

Anupam Saini¹

1Department of Pharmaceutical Chemistry, Institute of Pharmaceutical Research, GLA University, Mathura-281406, Uttar Pradesh, India

2Department of Pharmaceutics, M.M College of Pharmacy, Maharishi Mardandeshwar (Deemed to be University), Mullana, Ambala, Haryana, India

3Department of Medical Sciences, M. M. University, Solan, Himachal Pradesh, India

Journal of Reports in Pharmaceutical Sciences:Vol. 9, issue 2; 271-8

Published online:Oct 07, 2020

Article type:Systematic Review

Received:Sep 17, 2019

Accepted:Nov 09, 2019

How to Cite:Amandeep -Shailendra BhattManish KumarSheetal DeviPrabhat Kumar UpadhyayVipin SainiAmit MittalNavneet MehanAnupam Sainiet al.Recent Advances in the Development of the Nanostructured Lipid Carriers for the Topical Fungal Infections.J Rep Pharm Sci.9(2):e147122.https://doi.org/10.4103/jrptps.JRPTPS_99_19.

Abstract

Topical fungal infections are one of the often faced diseases worldwide. The first choice for the treatment of fungal infection is topical therapy due to its advantages such as decreasing the risk of systemic side effects and targeting the drug at the site of fungal infection. The treatment of the fungal infection depends on the penetration of the drug molecules through the outermost layer of the skin (stratum corneum) at an effective concentration. The disadvantages of topical treatment are its lack of drug adherence at the site of application and bigger particle size of drug molecules. Nanostructured lipid carriers are the advanced form of lipid nanoparticles and carry the nano range of the drug molecules, which helps to achieve localized and slow release. The topical route is generally preferred due to the possible side effects of oral medication. Advances in the field of formulation may soon render outdated conventional products such as creams, ointments, and gels. Several carrier systems loaded with antifungal drugs have shown promising results in the treatment of skin fungal infections.

Keywords

Fungal infection

lipid nanoparticles

nanostructured lipid carriers

topical

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Author(s):

Amandeep -:[PubMed][Scholar]
Shailendra Bhatt:[PubMed][Scholar]
Manish Kumar:[PubMed][Scholar]
Sheetal Devi:[PubMed][Scholar]
Prabhat Kumar Upadhyay:[PubMed][Scholar]
Vipin Saini:[PubMed][Scholar]
Amit Mittal:[PubMed][Scholar]
Navneet Mehan:[PubMed][Scholar]
Anupam Saini:[PubMed][Scholar]