Anxiolytic and Antidepressant Effects of Aqueous Extract of Stachys lavandulifolia Vahl. in Mice

Masuod Modarresi; Ahmad Mohammadi-Farani; Keyvan Amirshahrokhi; Rezvan Beheshtizadeh

doi:10.4103/jrptps.JRPTPS_108_19

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https://doi.org/10.4103/jrptps.JRPTPS_108_19

Anxiolytic and Antidepressant Effects of Aqueous Extract of Stachys lavandulifolia Vahl. in Mice

Author(s):

Masuod Modarresi^{1, 2},

Ahmad Mohammadi-Farani^{1, 3,*},

Keyvan Amirshahrokhi⁴,

Rezvan Beheshtizadeh⁵

1Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Department of Pharmacognosy and Pharmaceutical Biotechnology, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Department of Pharmacology, Toxicology and Medical Services, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

4Department of Pharmacology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran

5Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 9, issue 1; 31-40

Published online:Jun 26, 2020

Article type:Research Article

Received:Oct 01, 2019

Accepted:Feb 19, 2020

How to Cite:Masuod ModarresiAhmad Mohammadi-FaraniKeyvan AmirshahrokhiRezvan BeheshtizadehAnxiolytic and Antidepressant Effects of Aqueous Extract of Stachys lavandulifolia Vahl. in Mice.J Rep Pharm Sci.9(1):e147278.https://doi.org/10.4103/jrptps.JRPTPS_108_19.

Abstract

Background: Stachys lavandulifolia Vahl. is a widely used plant in Iranian traditional medicine. It has long been used as an anxiolytic herb. The aim of this work was to investigate the anxiolytic and antidepressant properties of aqueous extract of aerial parts of Stachys lavandulifolia Vahl. in mice.
Materials and Methods: For evaluation of anxiolytic and antidepressant effects of the plant, different doses (500, 1000, 1200, and 1400 mg/kg) of the extract were used in the mouse models of elevated plus maze (EPM) and forced swimming test (FST), respectively. The possible anxiolytic mechanism of the extract was determined by using pentylenetetrazol (PTZ) (10 mg/kg), propranolol (0.2 mg/kg), and atropine (0.5 mg/ kg). Sedative effect of the extract was evaluated by ketamine sleeping time test, and rotarod was used to determine the effects of the extract on motor function. Statistical analysis was performed using one-way analysis of variance (ANOVA).
Results: The results showed that the percentage of time spent and number of entries is significantly increased (P < 0.05) with doses of 1000 and 1200 mg/kg of the extract. PTZ but not propranolol or atropine reversed the effects of the extract (1000 mg/kg) on EPM. Neither doses of the extract could decrease the immobility of the mice in FST (P >0.05). Motor coordination was impaired (all doses) by the plant.
Conclusion: This study confirms the anxiolytic properties of aqueous extract of S. lavandulifolia and suggests that its effects are mediated through GABAA receptors. The extract does not have sedative properties but the results are indicative of a coordination impairing potential of the extract.

Keywords

Antidepressant

anxiolytic

mechanism

Stachys lavandulifolia Vahl

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Author(s):

Masuod Modarresi:[PubMed][Scholar]
Ahmad Mohammadi-Farani:[PubMed][Scholar]
Keyvan Amirshahrokhi:[PubMed][Scholar]
Rezvan Beheshtizadeh:[PubMed][Scholar]