Appraising the Neuroprotective Competence of Nitrogen-Enriched Arthrospira platensis in Comparison to Commercial Resource in Depressed Mice Models

Arockiya Anita Margret; Muppliyan Kalaiyarasan; Arockiya Avila Jerley; Theboral Jeevaraj

doi:10.4103/jrptps.JRPTPS_54_18

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https://doi.org/10.4103/jrptps.JRPTPS_54_18

Appraising the Neuroprotective Competence of Nitrogen-Enriched Arthrospira platensis in Comparison to Commercial Resource in Depressed Mice Models

Author(s):

Arockiya Anita Margret^1,*,

Muppliyan Kalaiyarasan¹,

Arockiya Avila Jerley²,

Theboral Jeevaraj¹

1Department of Biotechnology and Bioinformatics, Bishop Heber College, Tiruchirappalli, Tamil Nadu, India

2Department of Zoology, Holy Cross College, Tiruchirappalli, Tamil Nadu, India

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 2; 139-48

Published online:Dec 31, 2019

Article type:Research Article

How to Cite:Arockiya Anita MargretMuppliyan KalaiyarasanArockiya Avila JerleyTheboral JeevarajAppraising the Neuroprotective Competence of Nitrogen-Enriched Arthrospira platensis in Comparison to Commercial Resource in Depressed Mice Models.J Rep Pharm Sci.8(2):e147325.https://doi.org/10.4103/jrptps.JRPTPS_54_18.

Abstract

Background: Arthrospira platensis encompasses vital nutrients and is commercialized globally. It comprises of imperative resource that has the potential to combat neurological deformities caused due to stress and anxiety.
Objective: This work evaluates the neuroprotective effect of spirulina cultivated on nitrogen enriched medium and compares it with the commercial samples.
Materials and Methods: The study is authenticated with an antioxidant assay and the vital compounds are relatively profiled by GC-MS study. Furthermore, a molecular docking analysis is implemented to investigate the therapeutic potentials of the phytocompounds against Monoamine Oxidase –A and establish them as inhibitors. The ethanolic extract of spirullina as are fed on depressed mice models to assay its neuroprotective effect and rehabilitation of brain cells by a histopathological study.
Results: The antioxidant content of the augmented sample was consistent on par with the commercial sample. The in silico assay was performed with 10 extricated compounds of both the samples where, Butanoic acid, 3-hydroxy- furnished a minimum binding affinity energy value of -56.24 kcal/mol and dodecanamide was efficient to bind with the active site of the amino acid residue TYR 69 with a minimum energy of -87.8 kcal/mol. The histopathological examination upholds the refurbished parameter of vital phytocompounds with placid cellular edema and perivascular infiltration.
Conclusion: There is a wide range of need to develop research against stress and anxiety and the study fortifies the restorative efficacy of the phytocompounds as a neuroprotective drug.

Keywords

Arthrospira platensis

butanoic acid 3-hydroxy-

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Author(s):

Arockiya Anita Margret:[PubMed][Scholar]
Muppliyan Kalaiyarasan:[PubMed][Scholar]
Arockiya Avila Jerley:[PubMed][Scholar]
Theboral Jeevaraj:[PubMed][Scholar]