In vitro Anti‑Leishmanial Activity of Satureja khuzestanica Jamzad and Oliveria decumbens Vent. Extracts on Leishmania major and Leishmania infantum Promastigotes

Shahram Khademvatan; Alborz Eskandari; Batool Sadeghi-Nejad; Shahla Najafi

doi:10.4103/jrptps.jrptps_39_18

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https://doi.org/10.4103/jrptps.jrptps_39_18

In vitro Anti‑Leishmanial Activity of Satureja khuzestanica Jamzad and Oliveria decumbens Vent. Extracts on Leishmania major and Leishmania infantum Promastigotes

Author(s):

Shahram Khademvatan¹,

Alborz Eskandari²,

Batool Sadeghi-Nejad^3,*,

Shahla Najafi⁴

1Department of Myco-Parasitology, Urmia University of Medical Sciences, Urmia, Iran

2Department of Medicinal Chemistry, Faculty of Pharmacy, Ahvaz Jundishapour University of Medical Sciences, Ahvaz, Iran

3Abadan School of Medical Sciences, Abadan, Iran

4Department of Biology, Facultyof Science, University of Zabol, Zabol, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 2; 149-54

Published online:Dec 31, 2019

Article type:Research Article

How to Cite:Shahram KhademvatanAlborz EskandariBatool Sadeghi-NejadShahla NajafiIn vitro Anti‑Leishmanial Activity of Satureja khuzestanica Jamzad and Oliveria decumbens Vent. Extracts on Leishmania major and Leishmania infantum Promastigotes.J Rep Pharm Sci.8(2):e147369.https://doi.org/10.4103/jrptps.jrptps_39_18.

Abstract

Background and Objectives: Leishmaniasis is the main health problem and affects millions of people, especially in developing countries. On the other hand, there is no immunoprophylaxis (vaccination) accessible for the treatment of Leishmania infections and commercial drugs are unsatisfactory. Therefore, there is an effort to find alternative herbal remedies. The objective of the present study was to state the antileishmanial activity of two herbal medicines such as Satureja khuzestanica Jamzad and Oliveria decumbens Vent. leaf extracts on the promastigotes of Leishmania major and Leishmania infantum.
Materials and Methods: The hydroethanolic extracts of each plant were extracted and their antileishmanial effects evaluated in different concentrations (0–156 μg/ml) and at various hours (24, 48, and 72 h) using colorimetric (3[4, 5dimethylthiazol2yl]2, 5 diphenyltetrazolium bromide) assay. The concentrationresponse curves of tested extracts and glucantime solutions as a reference were designed, and 50% of inhibitory concentration (IC50) values were recorded.
Results: Antileishminal activity of S. khuzestanica, O. decumbens, and glucantime drug on L. major and L. infantum promastigotes were revealed with IC50 values of 4.3 and 5.5 μg/ml for S. khuzestanica, 0.85 and 0.23 μg/ml for O. decumbens, and 40.2 and 18.5 μg/ml for glucantime after 72 h incubation.
Conclusion: These results revealed that compounds from S. khuzestanica and O. decumbens have antileishmania properties that necessary to survey the effects of these extracts on leishmania genus in animal models in the future.

Keywords

Satureja khuzestanica

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Author(s):

Shahram Khademvatan:[PubMed][Scholar]
Alborz Eskandari:[PubMed][Scholar]
Batool Sadeghi-Nejad:[PubMed][Scholar]
Shahla Najafi:[PubMed][Scholar]