Characterization and Application of Borassus aethiopum (Arecaceae) Shoot Pregelatinized Starch as Binding Agent in Paracetamol Tablets

Chukwuemeka Paul Azubuike; Uloma Ubani-Ukoma; Shadrack Joel Madu; Oluwateniola Yomi-Faseun; Suliat Yusuf

doi:10.4103/jrptps.jrptps_29_18

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https://doi.org/10.4103/jrptps.jrptps_29_18

Characterization and Application of Borassus aethiopum (Arecaceae) Shoot Pregelatinized Starch as Binding Agent in Paracetamol Tablets

Author(s):

Chukwuemeka Paul Azubuike^1,*,

Uloma Ubani-Ukoma¹,

Shadrack Joel Madu²,

Oluwateniola Yomi-Faseun²,

Suliat Yusuf²

1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, College of Medicine Campus, Surulere Lagos, Nigeria

2Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Borno State, Nigeria

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 2; 172-80

Published online:Dec 31, 2019

Article type:Research Article

How to Cite:Chukwuemeka Paul AzubuikeUloma Ubani-UkomaShadrack Joel MaduOluwateniola Yomi-FaseunSuliat YusufCharacterization and Application of Borassus aethiopum (Arecaceae) Shoot Pregelatinized Starch as Binding Agent in Paracetamol Tablets.J Rep Pharm Sci.8(2):e147376.https://doi.org/10.4103/jrptps.jrptps_29_18.

Abstract

Aims: The study sought to characterize the physicochemical properties and assess the binding properties of pregelatinized starch (PGSb) derived from Borassus aethiopum shoot at various concentrations in paracetamol (PCM) tablet formulation.
Methods and Materials: PGSb was obtained by suspending 100 g of the native starch (NS) in 100 ml of deionized water at 55°C for 10 min. PGSb was characterized using different techniques and compared with a commercial brand of pregelatinized starch (PGSs). The compatibility of PGSb with PCM powder was evaluated using Fouriertransform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC) techniques. Three batches of PCM granules containing different concentrations of the PGSb as test binder were formulated and compared with two batches containing 1.78% polyvinylpyrrolidone and 1.78% NS as binder, respectively.
Results: The evaluated parameters of PGSb were comparable to PGSs. PGSb had improved solubility, lower gelatinization temperature, and better hydration capacity properties compared to the NS. FTIR and DSC studies confirmed the modification of the NS and its compatibility with PCM powder. The tablets formulated were within acceptable limits for the parameters evaluated (tablet thickness, uniformity of weight, hardness, friability, disintegration, and dissolution profile) except the batch that contained NS as binder that failed uniformity of weight and friability tests. All the batches released more than 70% of the active drug at 30 min. The dissolution study indicated that there were variations in the drug release profiles among tablets formulated with different binding agents.
Conclusions: The findings of this study indicate that PGSb has desirable physicochemical and binding properties.

Keywords

Binding potentials

Borassus aethiopum shoot

physicochemical characterization

pregelatinized starch

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Author(s):

Chukwuemeka Paul Azubuike:[PubMed][Scholar]
Uloma Ubani-Ukoma:[PubMed][Scholar]
Shadrack Joel Madu:[PubMed][Scholar]
Oluwateniola Yomi-Faseun:[PubMed][Scholar]
Suliat Yusuf:[PubMed][Scholar]