Age Peculiarity Manifestation of Antioxidant Effect of 6-hexyl-3,6-dimethyl- 6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-one on Rats under the Intermittent Hypobaric Hypoxia

Volodymyr Mykolayovuch Shvets; Alexei Yuriyevich Voskoboynik; Galina Grigorievna Berest; Sergiy Ivanovych Kovalenko; Maxim Vyacheslavovich Agibailov; Oleg Konstantynovuch Kulchitskiy; Nataliya Olegivna Kulchitska; Vadim Vyacheslavovich Davydov

doi:10.4103/jrptps.JRPTPS_30_19

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https://doi.org/10.4103/jrptps.JRPTPS_30_19

Age Peculiarity Manifestation of Antioxidant Effect of 6-hexyl-3,6-dimethyl- 6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-one on Rats under the Intermittent Hypobaric Hypoxia

Author(s):

Volodymyr Mykolayovuch Shvets^1,*,

Alexei Yuriyevich Voskoboynik²,

Galina Grigorievna Berest³,

Sergiy Ivanovych Kovalenko²,

Maxim Vyacheslavovich Agibailov⁴,

Oleg Konstantynovuch Kulchitskiy⁵,

Nataliya Olegivna Kulchitska⁶,

Vadim Vyacheslavovich Davydov⁷

1Department of Biochemistry, Zaporizkij Derzhavnij Medichnij Universitet, Zaporizhzhya, Ukraine

2Department of Organic and Bioorganic Chemistry, Zaporizkij Derzhavnij Medichnij Universitet, Zaporizhzhya, Ukraine

3Department of Pharmacognosy, Pharmacology and Medicine Technology, Zaporizkij Derzhavnij Medichnij Universitet, Zaporizhzhya, Ukraine

4Department of Clinical Pharmacy, Pharmacotherapy, Management and Economics of Pharmacy, Zaporizkij Derzhavnij Medichnij Universitet, Zaporizhzhya, Ukraine

5Department of Biology of Aging, Institute of Gerontology, Kiev, Ukraine

6Metabolism regulation laboratory, Institute of Gerontology, Kiev, Ukraine

7Department of Biochemistry and Molecular Biology, Rossijskij Nacional'nyj Issledovatel'skij Medicinskij Universitet Imeni N I Pirogova, Moscow, Russia

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 2; 295-7

Published online:Dec 31, 2019

Article type:Rapid Communication

How to Cite:Volodymyr Mykolayovuch ShvetsAlexei Yuriyevich VoskoboynikGalina Grigorievna BerestSergiy Ivanovych KovalenkoMaxim Vyacheslavovich AgibailovOleg Konstantynovuch KulchitskiyNataliya Olegivna KulchitskaVadim Vyacheslavovich Davydovet al.Age Peculiarity Manifestation of Antioxidant Effect of 6-hexyl-3,6-dimethyl- 6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-one on Rats under the Intermittent Hypobaric Hypoxia.J Rep Pharm Sci.8(2):e147416.https://doi.org/10.4103/jrptps.JRPTPS_30_19.

Abstract

Background: The organism of an old human as well as an experimental animal has decreased adaptive abilities and increased sensitivity to the effect of adverse environmental factors. We point out the high relevance of the search of new pharmacological compounds that have strong antioxidant properties and can be used to treatment and prevention of cardiovascular diseases with ageing.
Aims and Objective: The aim of the study was to investigate the antioxidant activity of 6-hexyl-3,6-dimethyl-6,7-dihydro- 2H-[1,2,4]triazino[2,3-c]quinazolin-2-one (HTQ).
Materials and Methods: Two groups of nonlinear male Wistar rats: 6–8 months (adult) and 24–26 months (old) were used. Determination of the myocardial diene conjugates and products reacting with 2-thiobarbituric acid (TBA-AP) concentration was carried out.
Results: Concentrations of diene conjugates in adult and old rats, which were administered HTQ, were 21% and 32%, respectively, lower compared to animals to which the synthesized compound was not administered. After administration of HTQ, the concentration of TBA-AP in old animals decreased by 23% as compared with the animals of the control group.
Conclusion: An administration of HTQ has limited the accumulation of intermediate lipid peroxidation products in the hearts of old animals in the condition of hypoxia.

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Author(s):

Volodymyr Mykolayovuch Shvets:[PubMed][Scholar]
Alexei Yuriyevich Voskoboynik:[PubMed][Scholar]
Galina Grigorievna Berest:[PubMed][Scholar]
Sergiy Ivanovych Kovalenko:[PubMed][Scholar]
Maxim Vyacheslavovich Agibailov:[PubMed][Scholar]
Oleg Konstantynovuch Kulchitskiy:[PubMed][Scholar]
Nataliya Olegivna Kulchitska:[PubMed][Scholar]
Vadim Vyacheslavovich Davydov:[PubMed][Scholar]