Antioxidant Effects of Amygdalin on Tunicamycin-induced Endoplasmic Reticulum Stress in the Mice Liver: Cross Talk between Endoplasmic Reticulum Stress and Oxidative Stress

Azam Moslehi; Tahereh Komeili Movahed; Mohammad Moslehi

doi:10.4103/jrptps.JRPTPS_35_19

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https://doi.org/10.4103/jrptps.JRPTPS_35_19

Antioxidant Effects of Amygdalin on Tunicamycin-induced Endoplasmic Reticulum Stress in the Mice Liver: Cross Talk between Endoplasmic Reticulum Stress and Oxidative Stress

Author(s):

Azam Moslehi

^1,*,

Tahereh Komeili Movahed¹,

Mohammad Moslehi²

1Cellular and Molecular Research Center, Qom University of Medical Sciences and Health Services, Qom, Iran

2Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences and Health Services, Tehran, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 2; 298-302

Published online:Dec 31, 2019

Article type:Rapid Communication

How to Cite:Azam MoslehiTahereh Komeili MovahedMohammad MoslehiAntioxidant Effects of Amygdalin on Tunicamycin-induced Endoplasmic Reticulum Stress in the Mice Liver: Cross Talk between Endoplasmic Reticulum Stress and Oxidative Stress.J Rep Pharm Sci.8(2):e147420.https://doi.org/10.4103/jrptps.JRPTPS_35_19.

Abstract

Context: Both endoplasmic reticulum (ER) stress and oxidative stress are involved in pathophysiology of many diseases. Recently, a cross talk between ER stress and oxidative stress has been identified. Amygdalin is an active ingredient in the seeds of apricots, bitter almonds, peaches, and other rosaceous plants.
Aim: This study was designed to evaluate the antioxidant effects of amygdalin on the liver-induced ER stress.
Materials and Methods: C57/BL6 inbred male mice were placed in five groups comprising saline, vehicle, and amygdalin as control groups. ER stress was induced by tunicamycin (TM) injection (ER stress group). Amygdalin was administered 1 h before TM challenge (ER stress + amygdalin group). Liver tissue supernatants were prepared and malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) were measured.
Results: The findings showed that ER stress increased MDA level and decreased SOD and CAT activity and GSH level (P < 0.05). Pretreatment with amygdalin decreased MDA concentration, whereas it increased SOD and CAT levels (P < 0.05).
Conclusion: This study showed that amygdalin attenuated TM-induced ER stress and has a considerable antioxidant activity in the liver tissue.

Keywords

Amygdalin

endoplasmic reticulum

liver

oxidative stress

tunicamycin

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Author(s):

Azam Moslehi:[PubMed][Scholar]
Tahereh Komeili Movahed:[PubMed][Scholar]
Mohammad Moslehi:[PubMed][Scholar]