Milk-Based Oral Formulations of Ibuprofen: An Investigation on the Role of Milk in Improving Dissolution Rate of Drug

Sukhmeet Singh Kamal; Daljit Kaur; Parminderjit Kaur; Amit Sharma; Ashish Kumar Garg; Charanjit Kaur; Gurvinder Singh; Rajesh Kumar

doi:10.4103/jrptps.jrptps_18_18

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https://doi.org/10.4103/jrptps.jrptps_18_18

Milk-Based Oral Formulations of Ibuprofen: An Investigation on the Role of Milk in Improving Dissolution Rate of Drug

Author(s):

Sukhmeet Singh Kamal¹,

Daljit Kaur¹,

Parminderjit Kaur²,

Amit Sharma^{1, 3},

Ashish Kumar Garg⁴,

Charanjit Kaur^{2, 3},

Gurvinder Singh^{2, 3},

Rajesh Kumar^{2, 3,*}

1Department of Pharmaceutics, Rayat Bahra Institute of Pharmacy, Hoshiarpur, Punjab, India

2Department of Pharmaceutical Sciences, Lovely School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

3PhD Research Scholar, IKG PTU, Jalandhar, Punjab, India

4Department of Pharmaceutics, Akal College of Pharmacy and Technical Education, Sangrur, Punjab, India

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 1; 47-54

Published online:Dec 31, 2019

Article type:Research Article

How to Cite:Sukhmeet Singh KamalDaljit KaurParminderjit KaurAmit SharmaAshish Kumar GargCharanjit KaurGurvinder SinghRajesh Kumaret al.Milk-Based Oral Formulations of Ibuprofen: An Investigation on the Role of Milk in Improving Dissolution Rate of Drug.J Rep Pharm Sci.8(1):e147471.https://doi.org/10.4103/jrptps.jrptps_18_18.

Abstract

Introduction: More than 40% of the newly developed drugs pose a problem of aqueous insolubility which is a major challenge for pharmaceutical scientists since in this form; drug doesn’t show required bioavailability and hence sufficient therapeutics effect.
Objective: The improvement of dissolution rate of ibuprofen (IBF) (poorly water-soluble drug) by formulating its solid dispersions using milk as generally recommended as safe carrier was the goal and purpose of this study.
Method: For this, milk containing 1.5% fat (named yellow milk due to yellow-colored pack) and milk containing 4.5% fat (named green milk due to green-colored pack) were used. Initially, both types of milk were rota evaporated to obtain free flowing powdered form. Then, the physical mixtures were prepared in different ratios by simple mixing and solid dispersions were formulated in different ratios by solvent evaporation method using hot air oven. Various techniques were used to evaluate and characterize the physical mixtures and solid dispersions, which included melting point determination, solubility studies, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy, X-ray diffraction (XRD), in vitro dissolution studies, and scanning electron microscopy (SEM).
Results: DSC and XRD studies showed reduction in peak intensity of drug indicating the conversion of crystalline drug into amorphous form. SEM studies indicated that the agglomerates formed were smaller and denser with a smooth surface. In vitro dissolution studies showed that the quantity of drug solubilized and the rate of dissolution increase after formulation into the solid dispersions.
Conclusion: The milk powder was found to enhance the solubility of IBF due to the presence of casein which entrapped the hydrophobic drug by forming micelles.

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Author(s):

Sukhmeet Singh Kamal:[PubMed][Scholar]
Daljit Kaur:[PubMed][Scholar]
Parminderjit Kaur:[PubMed][Scholar]
Amit Sharma:[PubMed][Scholar]
Ashish Kumar Garg:[PubMed][Scholar]
Charanjit Kaur:[PubMed][Scholar]
Gurvinder Singh:[PubMed][Scholar]
Rajesh Kumar:[PubMed][Scholar]