Role of Pea Protein Hydrolysates as Antinephrotoxicity

Meilinah Hidayat; Sijani Prahastuti; Teresa Liliana Wargasetia; Vincentius Ferdinand; Roro Wahyudianingsih; Andreanus Andaja Soemardji; Siti Farah Rahmawati; Nova Suliska; Khomaini Hasan

doi:10.4103/jrptps.jrptps_14_17

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https://doi.org/10.4103/jrptps.jrptps_14_17

Role of Pea Protein Hydrolysates as Antinephrotoxicity

Author(s):

Meilinah Hidayat^1,*,

Sijani Prahastuti²,

Teresa Liliana Wargasetia³,

Vincentius Ferdinand⁴,

Roro Wahyudianingsih⁴,

Andreanus Andaja Soemardji⁵,

Siti Farah Rahmawati⁵,

Nova Suliska⁵,

Khomaini Hasan⁶

1Nutrition Department, Faculty of Medicine, Universitas Kristen Maranatha, Bandung, Indonesia

2Biochemistry Department, Faculty of Medicine, Universitas Kristen Maranatha, Bandung, Indonesia

3Biology Department, Faculty of Medicine, Universitas Kristen Maranatha, Bandung, Indonesia

4Pathology Department, Faculty of Medicine, Universitas Kristen Maranatha, Bandung, Indonesia

5Pharmacology Department, Pharmacy School, Institut Teknologi Bandung, Indonesia, India

6Biochemistry Department, Jenderal Achmad Yani University, Jawa Barat, Indonesia

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 1; 55-60

Published online:Jun 30, 2019

Article type:Research Article

How to Cite:Meilinah HidayatSijani PrahastutiTeresa Liliana WargasetiaVincentius FerdinandRoro WahyudianingsihAndreanus Andaja SoemardjiSiti Farah RahmawatiNova SuliskaKhomaini Hasanet al.Role of Pea Protein Hydrolysates as Antinephrotoxicity.J Rep Pharm Sci.8(1):e147474.https://doi.org/10.4103/jrptps.jrptps_14_17.

Abstract

Introduction: Renal damage can be caused by various causes. One of them is drugs that are toxic to the renal, such as cisplatin (CP). In an attempt to find a remedy for antinephrotoxicity, several hydrolyzed proteins were investigated. This study was conducted to find out the effects of 8 peas protein hydrolysates (PPH) hydrolyzed using simple procedure to renal organ indexes (OIs) and histopathological features of CP-induced nephrotoxicity Wistar rats.
Materials and Methods: Protein hydrolysates of yellow peas, gude beans, green peas, and pea protein isolate (PPI) which hydrolyzed using neutrase or bromelain were administered to 50 female Wistar rats.The treatments were given for 30 days, and on day 7, all groups of rats, except negative control group, were injected CP intraperitoneal. Renal OIs were measured and kidneys were histopathological analyzed, which the results were converted to scoring system. Data were analyzed using ANOVA, LSD, Kruskal–Wallis, and Mann–Whitney test.
Results: Data of renal OIs were homogenous and normally distributed but were not significantly different between groups (P > 0.05).The nephrotoxicity of CP were not changing the renal OI but worsen the histopathological features of renal tubules in CP-induced rats (P < 0.01). All protein hydrolysate treatment groups showed less histopathological score than CP group. Green PPH hydrolyzed by bromelain-treatment group showed the lowest scores.
Conclusion: All PPH hydrolized with neutrase or bromelain improve the CP-induced nephrotoxicity rats. Green PPH with bromelain hydrolyzed had a promising potency as antinephrotoxicity.

Keywords

Antinephrotoxicity

bromelain

Cisplatin

green pea protein hydrolysate

kidney histopathological

organ index

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Author(s):

Meilinah Hidayat:[PubMed][Scholar]
Sijani Prahastuti:[PubMed][Scholar]
Teresa Liliana Wargasetia:[PubMed][Scholar]
Vincentius Ferdinand:[PubMed][Scholar]
Roro Wahyudianingsih:[PubMed][Scholar]
Andreanus Andaja Soemardji:[PubMed][Scholar]
Siti Farah Rahmawati:[PubMed][Scholar]
Nova Suliska:[PubMed][Scholar]
Khomaini Hasan:[PubMed][Scholar]