Evaluation the Effects of Cissus modeccoides Hot Aqueous Extract on Alloxan-induced Diabetic Rats

Waranee Pradit; Taddaow Khumpook; Kanokporn Saenphet; Supap Saenphet; Siriwadee Chomdej

doi:10.4103/jrptps.jrptps_19_18

Outlines

Abstract
Copyright

https://doi.org/10.4103/jrptps.jrptps_19_18

Evaluation the Effects of Cissus modeccoides Hot Aqueous Extract on Alloxan-induced Diabetic Rats

Author(s):

Waranee Pradit^{1, 2},

Taddaow Khumpook²,

Kanokporn Saenphet²,

Supap Saenphet²,

Siriwadee Chomdej^2,*

1Science and Technology Research Institute, Chiang Mai, Thailand

2Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 1; 85-90

Published online:Dec 31, 2019

Article type:Research Article

How to Cite:Waranee PraditTaddaow KhumpookKanokporn SaenphetSupap SaenphetSiriwadee ChomdejEvaluation the Effects of Cissus modeccoides Hot Aqueous Extract on Alloxan-induced Diabetic Rats.J Rep Pharm Sci.8(1):e147481.https://doi.org/10.4103/jrptps.jrptps_19_18.

Abstract

Introduction: In this study, the hypoglycemic effects and the safety of Cissus modeccoides (CM) were assessed on alloxan‑induced diabetic rats.
Methods: Various concentrations of CM hot aqueous extract were orally administered to alloxan‑induced diabetic rats for 30 days. Blood glucose level, hematological and biochemical parameters, and gene expression level were evaluated.
Results: After CM treatment, diabetic rats presented nonreduced blood glucose level and unimproved body weight. Increased blood urea nitrogen was observed in CM‑treated groups as well. Although hematological parameters and cholesterol level revealed nonsignificant effects from CM, decreased expression levels of the insulin receptor in the pancreas and insulin receptor substrate 2 and glucose transporter 2 in the liver were demonstrated in CM‑treated groups. Nephrin in the kidney of CM groups was highly expressed.
Conclusion: The results of this study revealed adverse effects and toxicity of CM extracts in diabetic rats.

Keywords

comments

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Metrics

Get Permission (article level)

Purchasing Reprints

Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here ( https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.

Search Relations

Author(s):

Waranee Pradit:[PubMed][Scholar]
Taddaow Khumpook:[PubMed][Scholar]
Kanokporn Saenphet:[PubMed][Scholar]
Supap Saenphet:[PubMed][Scholar]
Siriwadee Chomdej:[PubMed][Scholar]