In vitro Cytobiological Effects of Phytochemicals from Artemisia turanica

Mahboubeh Taherkhani

doi:10.4103/jrptps.jrptps_37_18

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https://doi.org/10.4103/jrptps.jrptps_37_18

In vitro Cytobiological Effects of Phytochemicals from Artemisia turanica

Author(s):

Mahboubeh Taherkhani^1,*

1Department of Chemistry, College of Science, Takestan Branch, Islamic Azad University, Takestan, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 8, issue 1; 106-13

Published online:Jun 30, 2019

Article type:Rapid Communication

How to Cite:Mahboubeh TaherkhaniIn vitro Cytobiological Effects of Phytochemicals from Artemisia turanica.J Rep Pharm Sci.8(1):e147486.https://doi.org/10.4103/jrptps.jrptps_37_18.

Abstract

Background: Phytochemicals from the plants have been used as traditional medicine and can cause many biological effects such as antimicrobial, anticancer, mutagenic and etc.
Aims: The subject of this research was to determine the chemical constituents and evaluate the antimicrobial, anticancer, cytotoxicity, mutagenic and anti mutagenic activities of the volatile oil of Artemisia turanica Krasch.
Material and Methods: Antimicrobial properties were measured by agar disc diffusion method. Cytotoxicity was determined through 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide method on human lymphocytes and cancer HeLa cells. Toxicity, mutagenesis, and anti-mutagenesis effects of the essential oil were measured by the Ames Salmonella mutagenicity method, in the existence or absence of S9 as a metabolic activation.
Results: Oxygenated monoterpenes, especially 1,8-cineole (35.2 %), α-thujone (24.2 %) and cis-chrysanthenol (16.8 %) were the main components in this volatile oil. Bactericidal kinetics of the volatile oil of A. turanica indicated that Esherichia coli is the most vulnerable one (minimal inhibitory concentration = 2.5 mg/ml, D value = 6.43 min). Cytotoxicity of the A. turanica oil in the human tumor cell line (17.67 μg/ml) was more than that observed in normal human lymphocytes (3291.49 μg/ ml). Volatile oil of A. turanica showed suitable antimutagenic potency on 2-nitrofluorene, in the strain of Salmonella typhimurium TA98, without the existence of metabolic activation S9.
Conclusion: The results achieved by human cells and with S. typhimurium prove that the volatile oil of A. turanica may be exploited as a natural anticancer and antimutagenic agent with low adverse side effects.

Keywords

Antimutagenic

Artemisia turanica

cytotoxicity

HeLa and lymphocyte cells

Salmonella typhimurium

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Author(s):

Mahboubeh Taherkhani:[PubMed][Scholar]