Effect of Combined Exposure to Chronic High Fat Diet and Arsenic on Kidney Function in Male Mice

Akram Ahangarpour; Azin Samimi; Leila Zeidooni; Soheila Alboghobeish; Layasadat Khorsandi; Ali Akbar Oroojan

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Effect of Combined Exposure to Chronic High Fat Diet and Arsenic on Kidney Function in Male Mice

Author(s):

Akram Ahangarpour¹,

Azin Samimi^2,*,

Leila Zeidooni²,

Soheila Alboghobeish³,

Layasadat Khorsandi⁴,

Ali Akbar Oroojan

⁵

1Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2Department of Toxicology, School of Pharmacy, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

3Department of Pharmacology, School of Medicine, Student Research Committee of Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

4Department of Histology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

5Department of Physiology, Student Research Committee of Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 7, issue 3; 240-249

Published online:Jun 19, 2018

Article type:Research Article

Received:Apr 07, 2018

Accepted:Jun 10, 2018

How to Cite:Akram AhangarpourAzin SamimiLeila ZeidooniSoheila AlboghobeishLayasadat KhorsandiAli Akbar Oroojanet al.Effect of Combined Exposure to Chronic High Fat Diet and Arsenic on Kidney Function in Male Mice.J Rep Pharm Sci.7(3):e147491.

Abstract

A number of risk factors could potentially affect the process of arsenic-induced kidney diseases. Arsenic is a common environmental and occupational contaminant dispersed world-wide, which can have an influence on developing chronic kidney disease (CKD) by several mechanisms. In recent years, alteration in the lifestyle as well as food habits among the people led to an increased use of food comprising a high-fat level. This important susceptible factor can have an effect on toxicity induced by arsenic. The present study was designed to evaluate the chronic exposure high fat diet (HFD) on arsenic-induced oxidative stress in kidney tissue of mice. Mice were randomly divided into 6 different groups (n=12). A low fat diet (LFD) control, LFD + arsenic 25 ppm, LFD + arsenic 50 ppm, HFD control, HFD + arsenic 25 ppm, HFD +arsenic 50 ppm. At the end of experiments, body weight and kidney weight to body weight ratio, biochemical parameters, oxidative stress markers, and kidney histological were evaluated. Our study showed that HFD increased arsenic-induced kidney damage through oxidative stress in mice. These investigations could be important for clinical research to protect against arsenic-induced kidney toxicity.

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