Formulation and Evaluation of Langsat (Lansium domesticum Corr.) Peel Ethanol extracts Lotion as Anti-Mosquito Repellent

Rama Hiola; Nurul Rizky; Hamsidar Hasan; Nurain Thomas

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Formulation and Evaluation of Langsat (Lansium domesticum Corr.) Peel Ethanol extracts Lotion as Anti-Mosquito Repellent

Author(s):

Rama Hiola^1,*,

Nurul Rizky²,

Hamsidar Hasan²,

Nurain Thomas²

1Department of Public Health, Faculty of Sport and Health, State University of Gorontalo, Indonesia

2Department of Pharmacy, Faculty of Sport and Health, State University of Gorontalo, Indonesia

Journal of Reports in Pharmaceutical Sciences:Vol. 7, issue 3; 250-259

Published online:Jun 19, 2018

Article type:Research Article

Received:Apr 09, 2018

Accepted:Jun 08, 2018

How to Cite:Rama HiolaNurul RizkyHamsidar HasanNurain ThomasFormulation and Evaluation of Langsat (Lansium domesticum Corr.) Peel Ethanol extracts Lotion as Anti-Mosquito Repellent.J Rep Pharm Sci.7(3):e147492.

Abstract

The repellent is a material that works in protecting humans from mosquito bites. Langsat peel (Lansium domesticum Corr.) is one of the plants having function as repellent, anti-mosquito containing triterpenoid compound. The purpose of this research was to formulate the langsat peel ethanol extract into anti-mosquito lotion and to determine the effectiveness of repellent anti-mosquito from the best formulation of the langsat peel ethanol extract. The Optimization of the lotion basis was performed on three variations of cetyl alcohol concentrations i.e. 3%, 5%, and 7% respectively and obtained F2 containing 5% Cetyl alcohol as the optimum base. The F2 lotion basis formula was formulated into lotion with three concentrations of 10%, 20%, and 35%. The three lotions formula of the langsat peel ethanol extract was tested by organoleptic test, preparation, spreading test, adhesion test and stability test, including pH and viscosity exposed at 15-30oC, 4oC and 40oC. All formulas were tested for irritation using rabbits for 3 days and did not show any erythema and edema. Tests of the effectiveness of anti-mosquito were done on rabbit using mosquitoes. The results obtained showed that langsat peel extract 20% and 35% had effectiveness as anti-mosquito repellent and can be formulated into lotion dosage form.

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