Antioxidant and Antiaging Activities of Jasminum Sambac Extract, and its Compounds

Wahyu Widowati; Widya Janeva B; Sri Nadya; Annisa Amalia; Seila Arumwardana; Hanna Sari Widya Kusuma; Yukko Arinta

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Antioxidant and Antiaging Activities of Jasminum Sambac Extract, and its Compounds

Author(s):

Wahyu Widowati^1,*,

Widya Janeva B¹,

Sri Nadya¹,

Annisa Amalia²,

Seila Arumwardana²,

Hanna Sari Widya Kusuma²,

Yukko Arinta²

1Medical Research Center, Faculty of Medicine, Maranatha Christian University, Jl. Prof. Drg. Surya Sumantri No. 65 Bandung 40164, West Java, Indonesia

2Aretha Medika Utama, Biomolecular and Biomedical Research Center, Jl. Babakan Jeruk 2, No. 9, Bandung 40163, West Java, Indonesia

Journal of Reports in Pharmaceutical Sciences:Vol. 7, issue 3; 270-285

Published online:Jul 03, 2018

Article type:Research Article

Received:Apr 25, 2018

Accepted:Jun 27, 2018

How to Cite:Wahyu WidowatiWidya Janeva BSri NadyaAnnisa AmaliaSeila ArumwardanaHanna Sari Widya KusumaYukko Arintaet al.Antioxidant and Antiaging Activities of Jasminum Sambac Extract, and its Compounds.J Rep Pharm Sci.7(3):e147496.

Abstract

Aging is a complex process characterized by a progressive decline in physiological function, followed by dysfunction, and ultimately, death. Increase activity of hyaluronidase, elastase and collagenase, are documented in skin aging. Free radicals can stimulate skin aging through antioxidant system destruction, wrinkle formation, and melanogenesis. Antioxidant and anti-aging agents have been recently developed from herbal plants. In this study, we investigated the antioxidant and anti-aging activities of Jasminum sambac extract (JSE). The phytochemical assay was performed with modified Farnsworth method. Antioxidant assays were measured by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenger, Ferric Reducing Antioxidant Power (FRAP) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS)-reducing activities. Anti-aging properties were measured through inhibitory activities of collagenase, elastase, and hyaluronidase. Phytochemical analysis showed presence of phenols, triterpenoids, and flavonoids in low level, and terpenoids in high level. JSE showed higher DPPH-scavenging activity (IC50=94.13 ± 10.54 μg/mL) than eugenol (2.28 ± 0.12 μg/mL), but lower than hesperidin (226.34 ± 4.96 μg/mL). JSE showed lowest ABTS-activity (IC50=39.20 ± 0.45 μg/mL) compared to hesperidin and eugenol (IC50= 8.10 ± 0.60 and 1.56 ± 0.03 μg/mL, respectively). The FRAP-reducing activity of JSE, hesperidin, and eugenol showed JSE was the lowest activity at highest concentration (65.46, 178.16 and 402.42 μM Fe(II)/μg) respectively). JSE showed the lowest anti-collagenase activity (IC50=339.30 ± 7.87 μg/mL), anti-elastase (IC50=249.94 ± 16.51 μg/mL), and anti-hyaluronidase (IC50=269.26 ± 90.52 μg/mL) compared to hesperidin, and eugenol. Overall, JSE has low antioxidant activity compared to hesperidin and eugenol, as well as low anti-collagenase, anti-elastase, and anti-hyaluronidase activities.

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