The Effect of Satureja avromanica Maroofi Extract on Oxidative Stress Induced by Malathion in Rats

Akram Ranjbar; Rasool Haddadi; Seyedeh Masoumeh Hosseini; Mohammad Mahdi Eftekharian; Dara Dastan

Outlines

Abstract
Copyright

The Effect of Satureja avromanica Maroofi Extract on Oxidative Stress Induced by Malathion in Rats

Author(s):

Akram Ranjbar^{1, 2},

Rasool Haddadi^{1, 2},

Seyedeh Masoumeh Hosseini^{1, 3},

Mohammad Mahdi Eftekharian⁴,

Dara Dastan^{1, 3,*}

1Medicinal Plants and Natural Products Research Center, Hamadan, Iran

2Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

3Department of Neurology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

4Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 7, issue 1; 108-115

Published online:Feb 13, 2018

Article type:Research Article

Received:Nov 22, 2017

Accepted:Dec 25, 2017

How to Cite:Akram RanjbarRasool HaddadiSeyedeh Masoumeh HosseiniMohammad Mahdi EftekharianDara DastanThe Effect of Satureja avromanica Maroofi Extract on Oxidative Stress Induced by Malathion in Rats.J Rep Pharm Sci.7(1):e147603.

Abstract

Malathion is an organophosphate (OP) pesticide that has been shown to induce oxidative stress in various organisms through the generation of free radicals and alteration of the cellular antioxidant defense system independent of its anticholinesterase effects. Satureja avromanica Maroofi species has been extensively investigated as a source of natural products with potential antioxidant and antimicrobial activity. The aim of this study was to investigate the possible protective role of hydroalcoholic extract effects of S.avromanica on interlokin17 (IL17), tumor necrosis factor (TNFα), total antioxidant capacity (TAC) and lipid peroxidation (LPO) in male rats poisoned with malathion. Effective doses of malathion (150 mg/kg/day) and S.avromanica extract (1000 mg/kg/day) were administered alone or in combination for 7 days by intraperitoneal injection. At the end of the experiment, the plasma of the animals was separated. In the blood plasma, the (IL17), (TNFα), (TAC) and LPO were measured. The results showed that the S.avromanica reduced the level of IL-17 compared to the control group, but this difference was significant only compared to the malathion group. Also, receiving S.avromanica caused increased serum TAC levels in rats, which this difference was significant compared to both control and malathion groups. In addition, it was observed that S.avromanica group showed significantly decreased in LPO level, compared to the group treated with malathion. As the results display, S.avromanica plant improves the oxidative stress status and related immune system factors.

Keywords

inflammation

Malathion

Oxidative toxic stress

Satureja avromanica

comments