Novel Super Saturated Self- Emulsifying System for Oral Delivery of Griseofulvin Design, Preparation and ex-vivo Intestinal Permeability

Behzad Sharif Makhmal Zadeh; Anayatollah Salimi; Rezvan Amini

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Novel Super Saturated Self- Emulsifying System for Oral Delivery of Griseofulvin Design, Preparation and ex-vivo Intestinal Permeability

Author(s):

Behzad Sharif Makhmal Zadeh^{1, 2},

Anayatollah Salimi

^{1, 2,*},

Rezvan Amini²

1Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 6, issue 2; 180-190

Published online:Aug 27, 2017

Article type:Research Article

Received:Jun 20, 2017

Accepted:Aug 20, 2017

How to Cite:Behzad Sharif Makhmal ZadehAnayatollah SalimiRezvan AminiNovel Super Saturated Self- Emulsifying System for Oral Delivery of Griseofulvin Design, Preparation and ex-vivo Intestinal Permeability.J Rep Pharm Sci.6(2):e147616.

Abstract

The Objective of the study was to prepare and design a stable formulation for self-emulsifying drug delivery system in order to enhance the solubility and oral absorption of a poorly-soluble drug, called griseofulvin. The prepared self-emulsifying systems were evaluated regarding their refractory index, particle size, emulsifying strength, drug release, and rat intestine permeability. The results showed that a mixture of oleic acid (as a fatty acid) with Labrafil-Tween 20 (as a surfactant), Labrafac PG (as a co-surfactant), and Poloxamer and hydroxypropyl methylcellulose (as a polymer) led to prepare stable emulsions with a refractive index higher than acidic medium and water. The particle size of the formulations was obtained between 310 to 834 nm. The particle size of samples was influenced by S/C ratios, so that the mean particle size decreases with an increasing in the S/C ratios. The percentage of drug release after 24 hours for formulations was 22.38 to 46.95. The correlation between the percentages of drug released after 24 hours with S/Oil and S/C ratios was significant. In Ex-vivo intestinal permeability, there was a significant and direct correlation between Q4 and surfactant/oil ratio. The selected formulations showed drug permeability through the rat intestine 3- folds more, compared with the control.

Keywords

Drug Release

Ex-vivo intestinal permeability

Griseofulvin

Oral Absorption

Self-Emulsifying Drug Delivery Systems

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