The Wound Healing Effect of Various Extracts from Onosma Microcarpum Root in a Diabetic Animal Model

Nasim Mohammadi; Gholamreza Bahrami; Nastaran Ghiasvand; Shahram Miraghaei; Seyed-Hamid Madani; Isaac Karimi; Yalda Shokoohinia

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The Wound Healing Effect of Various Extracts from Onosma Microcarpum Root in a Diabetic Animal Model

Author(s):

Nasim Mohammadi¹,

Gholamreza Bahrami²,

Nastaran Ghiasvand³,

Shahram Miraghaei²,

Seyed-Hamid Madani⁴,

Isaac Karimi⁵,

Yalda Shokoohinia

^3,*

1Student research committee, School of Pharmacy, 671451673, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Medical Biology Research Center, 6714415185, Kermanshah University of Medical Sciences, Kermanshah, Iran

3Pharmaceutical Sciences Research Center, School of pharmacy, 671451673, Kermanshah University of Medical Sciences, Kermanshah, Iran

4Department of Pathology, Kermanshah University of Medical Sciences, Kermanshah, Iran

5Laboratory of Molecular and Cellular Biology 1214, Department of Basic Veterinary Sciences, School of Veterinary Medicine, Razi University, Kermanshah, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 6, issue 1; 59-67

Published online:Mar 12, 2017

Article type:Research Article

Received:Dec 21, 2016

Accepted:Mar 05, 2017

How to Cite:Nasim MohammadiGholamreza BahramiNastaran GhiasvandShahram MiraghaeiSeyed-Hamid MadaniIsaac KarimiYalda Shokoohiniaet al.The Wound Healing Effect of Various Extracts from Onosma Microcarpum Root in a Diabetic Animal Model.J Rep Pharm Sci.6(1):e147623.

Abstract

Onosma microcarpum (Boraginaceae) locally known as “Tashnedary” is considered as one of important medicinal plants in west of Iran. Its roots have been used by the rural healers to treat the burns and wound healing.
In this study, different extracts of roots were used for the evaluation of its healing effect in diabetic wound model in rats. Diabetes was induced in Wistar rats, then wound incised on the back of rat, and subsequently they were divided into nine groups which eight of them contain eucerin with four concentrations of hexane extract (20%, 30%, 40%, 60%) and three other extract as aceton30%, ethanol30% and hydroEthanol30%, and one base eucerin without extract. Other formula was traditional formula and phenytoin. A photograph of the dorsum of the rat was taken from a standard height in days 0, 3, 6, 9, 15 and 20. Then, samples were processed in the pathologic surveys. Our study showed that the best result was demonstrated by Phenytoin cream treated group.
Our results indicated that like the general belief in west of Iran population, the ointment with n-Hex30% extracts of O. microcarpum could promote healing in described animal model, diabetic foot ulcer, compared to control.

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