Comparison of the Effects of Adding of Ketamine to Pre- Incisional Bupivacaine Injection on Postoperative Pain Relief after Tonsillectomy in Children

Mansour Choubsaz; Gholamreza Mohseni; Sara Jorair-Ahmadi; Masoud Sadeghi

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Comparison of the Effects of Adding of Ketamine to Pre- Incisional Bupivacaine Injection on Postoperative Pain Relief after Tonsillectomy in Children

Author(s):

Mansour Choubsaz¹,

Gholamreza Mohseni²,

Sara Jorair-Ahmadi¹,

Masoud Sadeghi^3,*

1Department of Anesthesiology, Kermanshah University of Medical Sciences, Kermanshah, Iran

2Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 6, issue 1; 68-76

Published online:Apr 10, 2017

Article type:Research Article

Received:Jan 05, 2017

Accepted:Apr 01, 2017

How to Cite:Mansour ChoubsazGholamreza MohseniSara Jorair-AhmadiMasoud SadeghiComparison of the Effects of Adding of Ketamine to Pre- Incisional Bupivacaine Injection on Postoperative Pain Relief after Tonsillectomy in Children.J Rep Pharm Sci.6(1):e147624.

Abstract

Pain control in children is still a therapeutic dilemma and preschool patients are affected from undesirable effects of postoperative pain more than adults. The aim of this work was to compare the effects of adding of Ketamine to pre-incisional Bupivacaine injection of post-operative pain relief after tonsillectomy. Sixty-three children that classified as ASA class I and II scheduled for adenotonsillectomy and divided into three groups (every group had 21 patients). Group 1: Bupivacaine (0.5%) 2mg/kg, Group 2: Ketamine 0.5 mg/kg and Group 3: Ketamine 0.5mg/kg and Bupivacaine (0.5%) 2mg/kg was injected into tonsillar bed by the surgeon. Side effects were evaluated at 1, 4 and 24 hours after adenotonsillectomy. The correlation between the data was done by Chi-square test and a P<0.05 was considered significant. One hour after surgery, in group 3, pain score was lower than other groups (P>0.05). Besides, after 4 hours in group 3, there was no severe pain in patients and higher percent of patients (61.9%) had mild pain compared to group 2 (P>0.05) and group 1 (P<0.05). After 24 hours, higher percent of patients without pain were in group 3 compared to group 2 (P>0.05) and group 1 (P=0. 05). In conclusion, adding of Ketamine to pre-incisional Bupivacaine injection resulted in post-operative acceptable pain relief with lower side effects after adenotonsillectomy.

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