Volatile Oil Constituent and Biological Activity of Gundelia Tournefortii L. From Iran

Dara Dastan; Morteza Yousefzadi

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Volatile Oil Constituent and Biological Activity of Gundelia Tournefortii L. From Iran

Author(s):

Dara Dastan^1,*,

Morteza Yousefzadi²

1Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran

2Department of Marine Biology, Faculty of Marine Sciences and Technology, Hormozgan University, Bandar Abbas, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 5, issue 1; 18-24

Published online:Mar 07, 2016

Article type:Research Article

Received:Jan 05, 2016

Accepted:Feb 28, 2016

How to Cite:Dara DastanMorteza YousefzadiVolatile Oil Constituent and Biological Activity of Gundelia Tournefortii L. From Iran.J Rep Pharm Sci.5(1):e147660.

Abstract

Gundelia tournefortii L. is an important food source and a well-known medicinal plant in Iran. In the present study, the Hydro-distilled volatile oil from the aerial parts of G. tournefortii was investigated by GC-MS and GC. A total of 41 compounds representing 96.2% of the volatile oil were identified. The main constituents were thymol (11.2%), γ-terpinene (9.8%), germacrene D (6.6%) and p-cymene (6.3%).
The antimicrobial activities of different extracts of G. tournefortii were examined against five Gram-positive and four Gram-negative bacteria. The antioxidant activities of different extracts were evaluated with DPPH radical scavenging activity and their relationship with the phenolic composition were also determined spectrophotometerically.
Methanol extract of G. tournefortii showed the strongest antioxidant activity (IC50= 40.3 μg/ml) and the highest total phenolic content (103.4 mgGA/g extract). Ethyl acetate extract demonstrated antibacterial effect against Bacillus cereus, Bacillus pumilus and Bacillus subtilis strains in concentration of 7.5 mg/ml.
The data of this study suggests that the essential oil and extracts from G. tournefortii has great potential for application as a prospective source of antioxidant and antimicrobial agent in pharmaceutical and food industries.

Keywords

Gundelia tournefortii L.

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