Polyamines Improve Anti-Blood Lactate Accumulation in an Acidosis Rat Model

Naghmeh Sattarahmady; Mozhgan Sedigh-Ardekani; Mohammad Ali Sahmeddini; Hossein Heli

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Polyamines Improve Anti-Blood Lactate Accumulation in an Acidosis Rat Model

Author(s):

Naghmeh Sattarahmady^{1, 2,*},

Mozhgan Sedigh-Ardekani¹,

Mohammad Ali Sahmeddini³,

Hossein Heli¹

1Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

2Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

3Shiraz Anesthesiology and Intensive Care Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 5, issue 1; 25-32

Published online:Mar 23, 2016

Article type:Research Article

Received:Dec 25, 2015

Accepted:Mar 03, 2016

How to Cite:Naghmeh SattarahmadyMozhgan Sedigh-ArdekaniMohammad Ali SahmeddiniHossein HeliPolyamines Improve Anti-Blood Lactate Accumulation in an Acidosis Rat Model.J Rep Pharm Sci.5(1):e147661.

Abstract

Lactic acidosis (lactate accumulation and pH downfall) occurs in a number of clinical conditions and has deleterious effects on the patient’s survival. Sodium bicarbonate and tromethamine are administrated in these conditions. However, these compounds adjust only the blood pH and do not affected the lactate level. In this study, administration of polyamines was hypothesized as a novel approach for treatment of lactate accumulation. For this purpose, the impact of different polyamines on the experimental model of acidosis was evaluated. In this study, the rats were divided into different groups and lactic acidosis type B was induced in them. Blood lactate was measured before and after acidosis in rats along with polyamines administration. Statistical analysis showed that polyamines such as putrescine, cadaverine and spermidine had significant effects on the lactate level, whereas sodium bicarbonate and tromethamine had no effect on it. These findings supported the advantageous effects of polyamines in treatment of lactate accumulation and can have implications for treatment of acidosis in human. Therefore, polyamines are proposed as an effective treatment for lactic acidosis.

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