Effects of Migriheal® on Plasma Proteome of Patients with Migraine Headaches

Setareh Mohammadpoor Masti; Mohammad Ansari; Mostafa Rezaei-Tavirani; Naser Nejadi; Hakimeh Zali; Mohammad Hessam Rafiee

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Abstract
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Effects of Migriheal® on Plasma Proteome of Patients with Migraine Headaches

Author(s):

Setareh Mohammadpoor Masti¹,

Mohammad Ansari^1,*,

Mostafa Rezaei-Tavirani

^2,**,

Naser Nejadi²,

Hakimeh Zali²,

Mohammad Hessam Rafiee³

1Biochemistry Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

2Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran

Corresponding Authors:

Journal of Reports in Pharmaceutical Sciences:Vol. 5, issue 1; 53-60

Published online:May 20, 2016

Article type:Research Article

Received:Feb 25, 2016

Accepted:May 15, 2016

How to Cite:Setareh Mohammadpoor MastiMohammad AnsariMostafa Rezaei-TaviraniNaser NejadiHakimeh ZaliMohammad Hessam Rafieeet al.Effects of Migriheal® on Plasma Proteome of Patients with Migraine Headaches.J Rep Pharm Sci.5(1):e147666.

Abstract

Recently, based on herbal medicine of Iran, an herbal drug with medical effects named MigriHeal®, has been registered; it helps in prevention of migraine headache strokes. In this study, MigriHeal was administered for pure migraine patients and the aim of this study is proteomic analysis of plasma from patients with migraine headaches before and after treatment with MigriHeal®. Before and after administration of MigriHeal®, patient's plasma was obtained, and then 2DE (2-dimensional electrophoresis) proteomic analysis of 11 patients was done. The Progenesis Same Spots ver.4 software was used for statistical analysis of the gels; according to ANOVA test analysis, we showed that the expression of two proteins named alpha-2-HS-glycoprotein (p-value: 0.023) and alpha-1-B-glycoprotein (p-value: 0.008) was decreased. Two identified proteins have anti-inflammatory effects and based on this finding we concluded inflammation is a pathologic mechanism of migraine, presumably, MigriHeal® has anti-inflammatory effects. Although these are not specific for the migraine and are altered in other diseases, these two proteins may be migraine biomarkers if measured simultaneously with quantitative methods in an expanded population.

Keywords

MigriHeal®

Migraine

Proteomics

2-dimensional electrophoresis

Herbal drugs

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