Aqueous Extract of Lavandula Angustifolia Alter Protein Expression in Alzheimer Rats

Masoud Soheili; Mahmoud Salami; Amirhossein Haghir; Hakimeh Zali; Mostafa Rezaei Tavirani

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Aqueous Extract of Lavandula Angustifolia Alter Protein Expression in Alzheimer Rats

Author(s):

Masoud Soheili¹,

Mahmoud Salami²,

Amirhossein Haghir³,

Hakimeh Zali⁴,

Mostafa Rezaei Tavirani^4,*

1Student Research Committee, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran

3Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

4Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 3, issue 1; 1-9

Published online:Jan 08, 2014

Article type:Research Article

Received:Oct 05, 2013

Accepted:Dec 26, 2013

How to Cite:Soheili M, Salami M, Haghir A, Zali H, Rezaei Tavirani M, Aqueous Extract of Lavandula Angustifolia Alter Protein Expression in Alzheimer Rats.J Rep Pharm Sci.2014;3(1):e147719.

Abstract

Alzheimer’s disease (AD) is a progressive and socio-economical form of dementia. The currently available drugs are only able to delay the symptom progression of the disease. This study tries to evaluate protein profile of the effects of aqueous extract of lavender (Lavandula angustifolia) on spatial performance of AD rats. Male Wistar rats were divided into control and Alzheimeric groups (CO and ALZ respectively). Rat model of AD was established by intracerebroventricular injection of 10 mg Aβ 1-42 twenty days prior to administration of the lavender extract. All of the groups were introduced to task learning in Morris water maze (MWM). After the first stage of spatial learning, control and Alzheimeric animals received 200 mg/kg of the lavender extract (CE200 and AE200 respectively) for 20 days. After the second stage of MWM, Hippocampus tissues of four groups were separated and protein profile was determined by 2DE. By using progenesis same spot software totally 950 spots were detected in 4 gel groups. Injection of amyloid beta suppresses expression of 111 proteins. Progressive Effects of lavender extract on spatial memory and maze learning task can be clear by finding difference gene expression in both ALZ and AE200 groups. Comparison between CO and CE200 groups show 80 new proteins that expressed and 104 protein that suppressed in CE200. These findings can disclose the efficiency of lavender on improving memory and learning. Applying more proteomics techniques to better understanding of protein changes can lead to the development of new drug treatments for dementia.

Keywords

Alzheimer disease

Proteomics

Lavandula Angustifolia

Hippocampus

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