Abstract
Alzheimer’s disease (AD) is a progressive and socio-economical form of dementia. The currently available drugs are only able to delay the symptom progression of the disease. This study tries to evaluate protein profile of the effects of aqueous extract of lavender (Lavandula angustifolia) on spatial performance of AD rats. Male Wistar rats were divided into control and Alzheimeric groups (CO and ALZ respectively). Rat model of AD was established by intracerebroventricular injection of 10 mg Aβ 1-42 twenty days prior to administration of the lavender extract. All of the groups were introduced to task learning in Morris water maze (MWM). After the first stage of spatial learning, control and Alzheimeric animals received 200 mg/kg of the lavender extract (CE200 and AE200 respectively) for 20 days. After the second stage of MWM, Hippocampus tissues of four groups were separated and protein profile was determined by 2DE. By using progenesis same spot software totally 950 spots were detected in 4 gel groups. Injection of amyloid beta suppresses expression of 111 proteins. Progressive Effects of lavender extract on spatial memory and maze learning task can be clear by finding difference gene expression in both ALZ and AE200 groups. Comparison between CO and CE200 groups show 80 new proteins that expressed and 104 protein that suppressed in CE200. These findings can disclose the efficiency of lavender on improving memory and learning. Applying more proteomics techniques to better understanding of protein changes can lead to the development of new drug treatments for dementia.
Keywords
Alzheimer disease Proteomics Lavandula Angustifolia Hippocampus
Copyright
© 2014, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.