Effect of Streptokinase on Short-term Outcomes in the Acute Myocardial Infarction with ST-Segment Elevation

Awat Feizi; Ali Nasr; Hamid Sanei; Peyman Mikaili; Afshin Amirpoor; Navab Ghasemi

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Abstract
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Effect of Streptokinase on Short-term Outcomes in the Acute Myocardial Infarction with ST-Segment Elevation

Author(s):

Awat Feizi¹,

Ali Nasr²,

Hamid Sanei²,

Peyman Mikaili³,

Afshin Amirpoor²,

Navab Ghasemi^2,*

1School of Health, Isfahan University of Medical Sciences, Isfahan, Iran

2School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

3School of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 3, issue 1; 85-89

Published online:Jun 14, 2014

Article type:Research Article

Received:Apr 25, 2014

Accepted:Jun 10, 2014

How to Cite:Feizi A, Nasr A, Sanei H, Mikaili P, Amirpoor A, et al. Effect of Streptokinase on Short-term Outcomes in the Acute Myocardial Infarction with ST-Segment Elevation.J Rep Pharm Sci.2014;3(1):e147731.

Abstract

Acute coronary syndrome is one of the most prevalent cardiovascular diseases. The acute myocardial infarction is one of its kinds which embodies the indication of fibrinolysis. One of the fibrinolytic types mostly used in Iran is Streptokinase (SK). This study aims to study the short-term clinical outcomes after receiving SK.A prospective cohort study was conducted on 54 patients at hospitals affiliated to Isfahan Medical School. After discharging, within 30 days, patients were followed regarding the morality and major adverse cardiac events (MACE) including Re-MI, unstable Angina, Cerebrovascular Accidents (CVA) and doing revascularization. Results were analyzed in both independent samples and Chi-square by statistical t-tests using SPSS software. Out of 54 patients, 25 individuals received SK versus 29 cases who did not receive that. In 30-day follow-up, no CVA or Re-MI was observed. In patients who did not receive SK, despite more deaths (14.2 % vs. 8 %) and MACE (62% vs. 56 %), it was not statistically significant (P>0.05).In the present study, receiving SK did not cause to reduce the rate of mortality and MACE in the time period of 30 days. However, it is suggested that a similar study with a larger size and also follow-up with long-term outcome be conducted.

Keywords

Streptokinase

Myocardial Infarction

Outcome

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Author(s):

Awat Feizi:[PubMed][Scholar]
Ali Nasr:[PubMed][Scholar]
Hamid Sanei:[PubMed][Scholar]
Peyman Mikaili:[PubMed][Scholar]
Afshin Amirpoor:[PubMed][Scholar]
Navab Ghasemi:[PubMed][Scholar]