Abstract
Multi-drug therapy in high blood pressure is appreciated to achieve a normal blood pressure. A simple spectrophotometric method based on principal component analysis has been proposed for simultaneous determination of amlodipine (Amd) and metoprolol (Met) in pharmaceutical preparations. Calibration matrix contains 3.402 μgml-1 to 170.130 μg ml-1 amlodipine and 13.7 μg ml-1 to 68.5 μgml-1 metoprolol. The proposed method was validated by using a set of synthetic sample mixtures and subsequently applied to simultaneous determination of amlodipine and metoprolol in different pharmaceutical preparations.
Keywords
Amlodipine Metoprolol Multivariate calibration Spectrophotometic Methods
Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.