Gastro Retentive Drug Delivery Systems: A Review

Khosro Adibkia; Saeed Ghanbarzadeh; Ghobad Mohammadi; Rahimeh Bairami Atashgah; Araz Sabzevari

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Gastro Retentive Drug Delivery Systems: A Review

Author(s):

Khosro Adibkia^{1, 2},

Saeed Ghanbarzadeh^2,*,

Ghobad Mohammadi^3,**,

Rahimeh Bairami Atashgah²,

Araz Sabzevari⁴

1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

2Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran

3Novel Drug Delivery Research Center, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran

4Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Corresponding Authors:

Journal of Reports in Pharmaceutical Sciences:Vol. 2, issue 2; 190-204

Published online:Jun 15, 2013

Article type:Research Article

Received:May 12, 2013

Accepted:Jun 10, 2013

How to Cite:Khosro AdibkiaSaeed GhanbarzadehGhobad MohammadiRahimeh Bairami AtashgahAraz SabzevariGastro Retentive Drug Delivery Systems: A Review.J Rep Pharm Sci.2(2):e147754.

Abstract

Gastric emptying is a complex and extremely variable process. This causes the unpredictability of the bioavailability of drug delivery systems. Gastro retentive drug delivery systems (GRDDS)s have received significant attention in the past decades primarily due to the fact that they can overcome the limitation of conventional oral controlled release drug delivery systems related to fast gastric emptying time. An optimum GRDDS can be defined as a system which remains in the stomach for a sufficient time interval and releases active ingredients in a controlled manner. This, significantly extends the duration of drug release, prolongs dosing interval and increases bioavailability of drugs and therefore improves compliance of the patients and effectiveness of pharmacotherapy. This article gives an overview of the main concepts used to design pharmaceutical dosage forms with prolonged gastric residence times as well as the parameters-affecting gastric emptying, advantages, shortcomings, formulation considerations and, factors that affect gastro retentive systems. The main emphasis is on the entire classification and different types of GRDDSs. Finally evaluation methods of these systems have been summarized.

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