Preparation and Physicochemical Evaluation of Nystatine Mucoadhesive Buccal Film

Rahim Bahri-Najafi; Mohammad Eghbali; Mohammad Peykanpour; Hamid Reza Mirzaei

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Preparation and Physicochemical Evaluation of Nystatine Mucoadhesive Buccal Film

Author(s):

Rahim Bahri-Najafi^1,*,

Mohammad Eghbali²,

Mohammad Peykanpour²,

Hamid Reza Mirzaei³

1Associate Professor, Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2Student of Pharmacy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

3Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 2, issue 1; 25-31

Published online:Feb 01, 2013

Article type:Research Article

Received:Jan 05, 2013

Accepted:Jan 22, 2013

How to Cite:Rahim Bahri-NajafiMohammad EghbaliMohammad PeykanpourHamid Reza MirzaeiPreparation and Physicochemical Evaluation of Nystatine Mucoadhesive Buccal Film.J Rep Pharm Sci.2(1):e147758.

Abstract

A new type of drug delivery system known as mucoadhesive film has been developed for oral thrush treatment. Due to comfortable use of this drug delivery system, this would be encouragingly utilized, especially in babies and patients under chemotherapy. Nystatinmucoadhesive film (NMF) is a polymeric film which is adhered to front upper gum and back to the upper lip and releases the drug within 5-6 hours in desired concentration. Because of sustained-release nature and permanent contact of drug with infectious agent of Candida albicans, the disease healing process would happen more rapidly, and in the meantime the patients can go on with their usual activities such as eating, drinking and talking without feeling the film in their mouth cavity. NMF was prepared using Eudragit RL100 and HPMC as film-forming constituents, and glycerin, propylene glycol and poly ethylene glycol 400 as plasticizers, according to casting method. Finally, physical appearance, weight, in vitro drug release rate and adhesion were assessed. with respect to considered parameters, prepared films with HPMC did not show uniform appearance; however, prepared films with Eudragit RL100 showed more desirable results and later showed longer drug release time with approximate time of 3.5 hours. Prepared NMF with dimensions of 2×1 Cm containing 10 mg nystatin using Eudragit RL100 polymer with mixture of glycerin, propylene glycol as plasticizer, not only showed desirable pharmaceutics characteristics but also exponential value (n) of 0.779 showed non-Fickian behavior of drug release.

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