Formulation and Evaluation of Sustained Release Dosage Form of Nifedipine Hydrochloride Using Hydrophilic Polymers

Mohammad Barzegar-Jalali; Jalal Hanaee; Yadollah Omidi; Saeed Ghanbarzadeh; Fatemeh Mizani Oskoii; Nazila Jafari Aghdam; Khosro Adibkia

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Formulation and Evaluation of Sustained Release Dosage Form of Nifedipine Hydrochloride Using Hydrophilic Polymers

Author(s):

Mohammad Barzegar-Jalali

^{1, 2},

Jalal Hanaee^{2, 3},

Yadollah Omidi^{4, 5},

Saeed Ghanbarzadeh^{2, 6},

Fatemeh Mizani Oskoii^{2, 6},

Nazila Jafari Aghdam^{2, 6},

Khosro Adibkia^{1, 2,*}

1Biotechnology Research Center, Tabriz University of Medical Science, Tabriz, Iran

2Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran

3School of Life Sciences, University of Bradford, Bradford, UK

4Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran

5Ovarian Cancer Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

6Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran

Journal of Reports in Pharmaceutical Sciences:Vol. 2, issue 1; 32-37

Published online:Feb 18, 2013

Article type:Research Article

Received:Jan 25, 2013

Accepted:Feb 15, 2013

How to Cite:Mohammad Barzegar-JalaliJalal HanaeeYadollah OmidiSaeed GhanbarzadehFatemeh Mizani OskoiiNazila Jafari AghdamKhosro Adibkiaet al.Formulation and Evaluation of Sustained Release Dosage Form of Nifedipine Hydrochloride Using Hydrophilic Polymers.J Rep Pharm Sci.2(1):e147759.

Abstract

Sustained release oral delivery systems are designed to achieve therapeutically effective concentrations of drug in the systemic circulation over an extended period of time. The purpose of the present investigation was to design and evaluate sustained release matrix tablets of nifedipine, a poorly water soluble drug, employing hydroxypropyl methyl cellulose (HPMC) and ethyl cellulose (EC) as hydrophilic polymers. Direct compression method was used to prepare matrix tablets. Drug content uniformity, friability test were performed and the in vitro drug release profiles were compared with the innovator product (Procardia) benefiting similarity factor (f2) and difference factor (f1). In all formulations content uniformity was in the acceptable range. Most of the prepared formulationspassed friability test. Formulation containing HPMC and EC in the ratio of 88.5:5 showed acceptable dissolution properties compared to reference formulation. Fitting the release data to the kinetic models indicated that the best fitted kinetic model for the prepared matrix tablets and Procardia were zero order and Weibull model, respectively. This study indicates that the hydrophilic matrix tablets of nifedipine prepared using HPMC and EC can successfully be employed as sustained release matrix tablet in order to improve patient compliance.

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