The damages caused by vehicles is one of the biggest health problems, the prevention of which requires effective and sustainable action. The main reasons underlying such events are individual, subjective, and social agents, such as substance-related disorders (
1,
2). Driving in Iran is one of the toughest jobs. Bad weather conditions, lack of amenities for resting, and separation from family are the most common hardships encountered by Iranian drivers. Vehicle drivers are susceptible to fatigue, drowsiness, musculoskeletal pain, and driving accident risks because they drive long hours in most cases. Some drivers believe that substance-related disorders can reduce fatigue and drowsiness, therefore, they are inclined to substance related disorders. On the other hand, researches have argued that any kind of substance that influences the nervous system and mind can contribute to driving risks (
3-
5).
Substance-related disorders can influence driving skills, safety of driving, attention and carefulness, reaction time, judgment, and problem solving skills (
5-
7). The results obtained from the study conducted by Zhou (2010) showed that drug testing was positive for 10.5% of drivers (
7). Regarding difficulties in giving up substance-related disorders and the relevant addiction recurrence, it is necessary to recognize risk factors causing the problem in different populations, including drivers.
Several factors and backgrounds contribute to addiction; one important factor is aggression. Many researchers have shown that taught pattern of conduct plays an important role in drug use. Some people believe that when they are solving a problem, they feel more anger and frustration, so they are tempted to use such substance in order to overcome these emotions (
8,
9). In a study conducted by Martinotti et al. (
10), it was shown that people experiencing failure and frustration may release their emotion in criminal activity and substance-related disorders. The authors in the study argue that anger and aggression play significant roles in substance-related disorders. Therefore, it seems that problematic behavior is a result of ineffective coping responses, culminating in uncontrolled anxiety and anger. Anger may contribute to non-adaptive coping responses, such as criminal action, including substance-related disorders. The research performed by Bushman as a prominent relevant study showed that there is a high correlation between anger and drug addiction (
11). The research conducted by Hayatbakhsh et al. showed that among factors influential on predicting the tendency to drugs, aggression plays an important role (
12). In another research conducted by Epstein et al. (
13), 517 teenagers were assessed. The study results showed that aggression and maladaptive behaviors are associated with taking drugs. Jaffe in his research sought to assess the relationship between aggression and drug use. The authors concluded that there is a positive correlation between aggression and drug use (
14).
Another variable that was influential on substance-related disorders is sleep quality. Sleep quality is one of the main circadian cycles and complex biological patterns having effect on physical and mental health (
15). Sleep is not influenced by time and processes of homeostasis, rather, some factors including environmental factors (e.g. sound), psychosocial factors (e.g. stress), physical illnesses (e.g. respiratory failure in the lungs), and lifestyle factors (such as alcohol, caffeine, and drug substances) can strongly influence sleep (
16). Low sleep quality can result in daily fatigue, irritability and lack of concentration. Along with earlier-mentioned factors, alcohol and drugs can influence individual tendency to addiction. On the other hand, alcohol and drug abuse can intensify sleep disorder and also lower sleep quality. As a result, a cycle is formed that can intensify sleep problem and tendency to drug use (
17-
20). Bootzin and Stevens conducted a study, in which they showed that teenagers, whose sleep problems were obviated had lower tendency to substance related disorders (
21). Ashoori assessed the relationship between sleep quality and temptation of using drugs among 83 addicted patients, and showed that there was a significant relationship between sleep quality and rate of temptation. In other words, a lower sleep quality is associated with higher rate of drug-use temptation in individual (
22).
Generally, substance-related disorders can be considered a serious problem that contribute to addiction. Assessing and recognizing factors associated with substance-related disorders is important because they cause many problems for human’s health. The factors effective on substance-related disorders in reckless drivers have been assessed for decades and the relationship between aggression and sleep quality was analyzed in previous studies, yet the variables were not assessed sufficiently in the samples of reckless drivers (
16,
19,
23,
24).
Therefore, the present study addressed this group of individuals. The reason underlying the examination of drug abuse in high-risk drivers was that drug abuse influences driving skills, balance and coordination, human understanding of driving, attention and accuracy, reaction time, and ultimately problem-solving skills of drivers. Drug abuse puts the individuals at risk, and endangers pedestrians and other people as well. Driving under these conditions can contribute to the risk of driving accidents and can badly affect the severity and consequences of an accident. On the other hand, factors, including sleeping habits and aggression and their control influences the reactions to driving conditions, cause numerous problems during driving, and culminate in numerous driving accidents. Therefore, with regards to the above and the effect of drug abuse on driving behavior, it is necessary to examine drug abuse consequences. It is noteworthy that previous studies have mostly examined the epidemiology of drug abuse among drivers and have failed to consider the predictive variables of drug abuse, such as sleep quality and aggression. Accordingly, the present study aimed at evaluating the function and effect of aggression and sleep quality in drug abuse among high-risk drivers.