This was a randomized clinical trial (registration number: IRCT20210804052078N1) conducted in Kashan in 2022. Adolescents were selected from 12-18-year-old children whose parents were suffering from a major depressive disorder or bipolar disorder undergoing outpatient treatment or receiving inpatient services at the Kargarnjad Hospital of Kashan. Inclusion criteria were the diagnosis of mood disorders in parents according to the DSM-5 scale, parents’ consent for their children to participate in the study, adolescents’ being aware of their parents' illnesses, and children’s willingness to participate. Exclusion criteria were the diagnosis of psychiatric illnesses in adolescents and missing more than two sessions of the peer-group support program. Clinical interviews were conducted based on SCID-5 CV with both parents and then their children by psychiatrists working in Kargarnejad Hospital to confirm the inclusion and exclusion criteria.
No parallel RCTs were found, so the sample size was calculated according to the parameters reported in a pre-post study by Foster et al. (
19) as α = 0.05 and β = 0.2. Using the formula specific for the before-after study design, the required sample size was obtained as 40. Regarding probable attrition, the final sample size was increased to 50 in each group.
After evaluating candidates for inclusion and exclusion criteria and observing ethical issues, each participant was assigned a unique code using SPSS software, 50 adolescents were allocated to the intervention group, and 50 others were assigned to the control group using the simple randomization method. In each group, 20 adolescents did not answer the study questionnaires, and the data from the remaining 60 adolescents were analyzed.
After explaining the program and its relevance to parents, the informed consent form was signed by parents, and then a demographic information form was completed by the adolescents and parents.
Before starting the project, adolescents in both groups completed two questionnaires: (1) Conner and Davidson’s resilience and (2) Rosenberg’s self-esteem. The participants in the intervention group were divided into groups of 6 to 8 of the same sex, and each group participated in 90-minute sessions held by a psychiatric assistant every week for eight consecutive weeks. Both groups answered the two questionnaires again at the end of the eight weeks.
Rosenberg’s self-esteem scale measures overall self-esteem, satisfaction with life, and a sense of worth. This questionnaire consists of ten items, and the subject is asked to respond on a four-point Likert scale ranging from "strongly agree" to "strongly disagree." The score on this scale ranges from 10 to 40, with higher scores indicating higher self-esteem. In Iran, Rajabi and Nasreen verified the reliability of this tool with Cronbach’s alpha coefficient of 0.84 (
20).
Connor and Davidson's Resilience Scale contains 25 statements rated on a Likert scale from 0 (totally false) to 5 (always true). The test score ranges from 0 to 100. A higher score indicates greater resilience. The scale consists of five subscales, including “personal competency, high standards, and tenacity”, “trust in one’s instincts, tolerance against negative emotions, and strengthening effects of stress”, “positive acceptance of change and secure relationships”, “control”, and “spiritual influences”. In Iran the reliability of this scale with Cronbach’s alpha coefficient of 0.95 was approved (
21).
3.1. Peer-group Support Program
The intervention sessions were facilitated by a trained psychiatric assistant according to the
Kids in Control Program and using the concepts from the books "Supportive Psychotherapy Learning Guide" (
22), "Depression: A Family Guide" (
23), and "Bipolar Disorder: A Family Guide" (
24), as well as the pamphlets available from the COPMI website. The psychiatry assistant also received supervision from a child and adolescent psychiatrist and a fellowship of psychotherapy specialist. The following topics were discussed during eight sessions in order:
(1) Introduction and establishing the feeling of belonging to a group, explaining group rules, confidentiality guidelines, creating a group identity, acquaintance with each other, and identifying the ability to make decisions.
(2) Obtaining an understanding of basic emotions, comprehending the terminology of primary emotions, and learning how to control emotions.
(3) The roles and responsibilities that adolescents should or shouldn’t take, appropriate ways to share feelings, and proper defenses.
(4) Understanding psychiatric diseases, their causes and physiological basis, and expressing the problems caused by the mental illness of parents.
(5) Understanding treatments and drugs, knowing false information about psychiatric illnesses, expressing how stigma affects one’s life, and managing feelings of shame or guilt towards parents.
(6) Understanding the meaning of resilience, discovering personal experiences of resilience, and promoting tools that strengthen it.
(7) Acquiring information about the meaning of self-esteem, discovering personal experiences of self-esteem, and recognizing individuals’ strengths and valuable abilities.
(8) The importance of self-care, ways to obtain approval, valuing oneself, and recognizing one’s and others’ special qualities.
Because each group’s experiences and needs were different and special, the groups did not follow the exact outline, and the content was modified according to the conditions of the meeting and the group. At the end of the program, satisfaction with group participation and perceptions of mood disorders were surveyed in interviews.
Data were presented using descriptive statistical measures (mean, standard deviation, and frequency) and analyzed using the independent samples Mann-Whitney U test, Fisher’s exact test, paired t-test, independent t-test, and Pearson chi-square test. Data were analyzed using SPSS 26. The statistical significance level was determined as P < 0.05 at a 95% confidence interval.