This randomized controlled trial compared the effects of ultrasound-guided PENG block and FN block on quadriceps muscle strength in patients with hip fractures undergoing surgery under spinal anesthesia. The results demonstrated a statistically significant preservation of quadriceps strength in the PENG block group compared to the FN block group both in the PACU after spinal anesthesia resolution and at 24 hours. Preservation of quadriceps muscle strength in the PENG block group is a key advantage, especially in elderly patients. Avoiding motor blockade — a known drawback of the FN block — enables earlier mobilization and reduces fall risk.
Post-operative VAS scores at rest were significantly lower in the PENG block group at 0, 1, 12, and 18 hours after spinal anesthesia wore off. During movement, the PENG block group also exhibited significantly lower VAS scores at 0, 30 minutes, 6, 12, and 24 hours. Additionally, the PENG block group demonstrated superior patient positioning quality for spinal anesthesia.
Pain and discomfort during positioning for spinal anesthesia are common in hip fracture surgery. Systemic analgesics in elderly patients may cause complications; thus, peripheral nerve blocks remain the gold standard, with the FN block frequently used. The PENG block, which provides motor-sparing analgesia by targeting the articular nerves of the hip, has recently been adopted for positional pain management (
15). Several studies emphasize the PENG block’s importance for post-operative pain control and quadriceps motor function recovery in hip fracture surgery. The PENG block selectively targets the sensory branches of the FN supplying the anterior hip capsule, providing effective analgesia without compromising motor function (
16).
Kong et al. (
17) confirmed the analgesic efficacy of the PENG block in intertrochanteric femur fractures, consistent with these findings. Et and Korkusuz (
18) reported earlier mobilization with the PENG block than with the quadratus lumborum block, providing motor-protective analgesia for up to three post-operative hours. Yu et al. (
19) noted unintentional quadriceps weakness in 2% of PENG block cases, possibly due to local anesthetic spread to the FN or iliac fascia space from medial or superficial needle tip placement.
Positioning for spinal anesthesia is influenced by pain management, affecting patient comfort and positioning quality (
20). In a comparative study by Jadon et al. (
21), the PENG block provided better positioning than the fascia iliaca compartment block. Alrefaey and Abouelela (
22) found that patients who received the PENG block had lower Ease of Spinal Position Scores and less pain while sitting for spinal anesthesia than controls, concluding that the PENG block is effective for managing positional pain.
Guay and Kopp (
23) conducted a meta-analysis showing significant pain reduction within 30 minutes of nerve block. Sahoo et al. (
24) similarly found that the PENG block in 20 hip fracture patients with VAS > 5 significantly reduced pain at rest and during 15° straight leg-raise after 30 minutes. Their subsequent study (
25) demonstrated significant decreases in VAS scores at 6, 12, and 24 hours post-PENG block, both at rest and during passive movement, supporting the PENG block’s effectiveness for pain relief.
A comparative analysis by Choi et al. (
26) found no significant differences between the PENG block and supra-inguinal fascia iliaca compartment block in post-operative pain scores or opioid consumption within 48 hours after total hip arthroplasty under general anesthesia; quadriceps strength also decreased similarly in both groups. Ye et al. (
27) reported that ultrasound-guided pericapsular nerve blockade did not reduce morphine consumption after total hip arthroplasty compared to local infiltration analgesia and did not provide superior analgesia or enhance hip function. Fahey et al. (
28) found no significant differences in adverse events or pain score reduction between experimental and control groups in a pilot study.
The FN is located at or beneath the inguinal ligament and is infiltrated with local anesthetic to block sensation in the anterior upper thigh, patella, and medial lower leg. The FN block is associated with quadriceps weakness, prolonged immobility, and increased risk of post-operative falls. Ghodki et al. (
29) reported that only 13% of patients receiving FN block attained normal quadriceps motor function 12 hours post-surgery, while 17% exhibited muscle weakness 24 hours after surgery.
By contrast, the PENG block preserves motor innervation by targeting only the sensory articular branches of the anterior hip capsule, avoiding quadriceps weakness and facilitating rapid post-operative mobilization. In contrast, the FN block affects quadriceps muscle motor innervation, resulting in motor weakness (
13).
Our findings of superior immediate post-operative analgesia with the PENG block are consistent with Lin et al. (
14), who observed improved pain control in the recovery room and greater quadriceps strength in the PENG block group compared to the FN block, supporting early mobilization. Chaudhary et al. (
30) also demonstrated superior analgesia with the PENG block for proximal femur fracture surgery, whereas the FN block group had longer analgesia but reduced quadriceps strength post-operatively. Erten et al. (
31) showed that the PENG block provides superior analgesia to the FN block for pain during lateral positioning, hip flexion, and lumbar flexion prior to spinal anesthesia in geriatric hip fracture surgery. Mistry and Sonawane (
32) found superior preservation of quadriceps strength in the PENG block group versus the FN block group in femoral fracture patients. Allard et al. (
33) reported that while post-operative morphine consumption and pain scores were similar between PENG and FN blocks, quadriceps muscle strength was better preserved in the PENG group, in line with these results. Recent systematic reviews, such as Wan et al. (
34), also suggest potential advantages of the PENG block over traditional techniques in hip arthroplasty.
Our findings demonstrate that the PENG block provides superior post-operative analgesia compared to the FN block following hip surgery, with lower VAS scores at multiple time points (both at rest and during movement) and a significantly longer analgesic duration (23.16 ± 2.10 hours vs. 19.92 ± 4.60 hours, P < 0.001). Although tramadol consumption was similar, the PENG block’s motor-sparing effect and improved pain profile underscore its clinical benefit.
The primary limitation of this study is its single-center design and relatively small sample size, limiting generalizability. Future studies with larger cohorts are needed. Another limitation inherent to regional anesthesia trials is the challenge of complete blinding; although the procedural anesthesiologist could not be blinded to block type, the patients, outcome assessor, and data analyst were fully blinded to minimize bias. The study did not include a control group; however, literature suggests that sham or placebo groups do not alter interpretation in regional anesthesia trials. Psychological factors (e.g., anxiety, pain catastrophizing) were not assessed preoperatively, despite their potential influence on pain scores. Follow-up was limited to 24 hours, and time to ambulation or length of hospital stay was not evaluated.
5.1. Conclusions
This study demonstrated that the PENG block provided superior and significantly longer-lasting analgesia, better preservation of quadriceps muscle strength, and improved patient positioning quality during spinal anesthesia compared to the FN block group. There were no significant differences between groups regarding post-operative complications or tramadol consumption.