Early Conversion to Tacrolimus Vs Cyclosporine Continuation in Normally Functioning Kidney Allograft: A Single-Center Study

Laya Azizzadeh; Seyed Amirhossein Fazeli; Farshad Hashemian; Sanaz Dehghani; Seyedeh Samaneh Ahmadi; Gholamreza Pourmand

doi:10.22037/ijpr.2020.113220.14174

IJ Pharmaceutical Research

Current Issue All Issues In Press Accepted Manuscripts

Journal Information Editors & Boards Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Reviewer and AE Registration Form Support Contact Us

APC

Authors Guide Submit Manuscript

https://doi.org/10.22037/ijpr.2020.113220.14174

Early Conversion to Tacrolimus Vs Cyclosporine Continuation in Normally Functioning Kidney Allograft: A Single-Center Study

Author(s):

Laya Azizzadeh¹,

Seyed Amirhossein Fazeli²,

Farshad Hashemian¹,

Sanaz Dehghani³,

Seyedeh Samaneh Ahmadi⁴,

Gholamreza Pourmand^3,*

1Department of Clinical Pharmacy, Faculty of pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

2Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran

3Urology Research Center, Sina Hospital, Tehran University of Medical sciences, Tehran, Iran

4Rajaie Cardiovascular, Medical, and Research Center, Iran University of Medical Sciences, Tehran, Iran

IJ Pharmaceutical Research:Vol. 19, issue 3; 556-571

Published online:Jul 31, 2020

Article type:Research Article

Received:Feb 01, 2020

Accepted:Jul 01, 2020

How to Cite:Azizzadeh L, Fazeli SA, Hashemian F, Dehghani S, Ahmadi SS, et al. Early Conversion to Tacrolimus Vs Cyclosporine Continuation in Normally Functioning Kidney Allograft: A Single-Center Study. Iran J Pharm Res. 2020;19(3):e127850. doi: https://doi.org/10.22037/ijpr.2020.113220.14174

Abstract

This study evaluated the effectiveness of early pre-emptive conversion from cyclosporine to tacrolimus in kidney transplant patients with normal graft function and in the absence of adverse effects of the initial cyclosporine. A historical cohort study of 166 patients who received deceased-donor kidney transplant between 2011 to 2017 was conducted. All the patients had been treated with cyclosporine (Sandimmune®) during their immediate post-transplantation period. At the time of hospital discharge, the patients were divided into 2 groups: patients with continued cyclosporine (Sandimmune®) treatment (n = 125) and the patients whose treatments converted from cyclosporine to tacrolimus (Prograf®) at discharge (n = 41). The 1-year graft function (p = 0.074), acute rejection (p = 0.566), and graft loss (p = 0.566) were not significantly different between two groups. The patients on tacrolimus had lower levels of cholesterol (p = 0.002) and diastolic blood pressure (p = 0.015). The long-term follow-up showed no significant difference in graft loss (p = 0.566). The patients received tacrolimus had higher all-cause mortality within the first year posttransplantation (p = 0.002) as well as long-term follow-up (p = 0.001). The continuation of initial cyclosporine might be a good option when the graft function is acceptable and the adverse effects are absent.

Keywords

Graft

Transplantation

Calcineurin inhibitors

Kidney

Immunosuppressive

Change of Cyclosporine Absorption over the Time After Kidney Transplantation

Behzad Einollahi,

Mojtaba Teimoori,

Zohreh Rostami

5

Feb

2019

Kidney Transplantation: Local Donor and Distant Recipient, Is It Feasible? A Retrospective Cross-Sectional Study

Behzad Einollahi,

Mohammad Hosein Nourbala,

Mahboob Lessan-Pezeshki,

Iman Lotfian,

Sharareh Sanei Sistani,

Aidin Lotfiazar

,et al.

20

Jan

2015

The Impact of Acute Rejection in Kidney Transplantation on Long-Term Allograft and Patient Outcome

Mojgan Jalalzadeh,

Nouraddin Mousavinasab,

Said Peyrovi,

Mohammad Hassan Ghadiani

29

Oct

2013

Dyslipidemia in Renal Transplant Recipients Treated With Cyclosporine A

Mariusz Niemczyk

11

Jan

2021

Evaluation of Cyclosporine and Tacrolimus Dose Changes During Post-transplantation Period and Their Association with Endomyocardial Biopsy Grading

Kambiz Mozaffari,

Ahmad Amin,

Mohammad Ahangarani Farahani,

Nasim Naderi,

Sepideh Taghavi,

Mohammad Mahdavi

,et al.

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 1
Last Update: 2 weeks ago
Scopus by Title: 1
Last Update: 2 weeks ago
Scopus by Title (Ref): 1
Last Update: 2 weeks ago
CrossRef: 0
Last Update: 9 hours ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Laya Azizzadeh:[PubMed][Scholar]
Seyed Amirhossein Fazeli:[PubMed][Scholar]
Farshad Hashemian:[PubMed][Scholar]
Sanaz Dehghani:[PubMed][Scholar]
Seyedeh Samaneh Ahmadi:[PubMed][Scholar]
Gholamreza Pourmand:[PubMed][Scholar]

Outlines

Early Conversion to Tacrolimus Vs Cyclosporine Continuation in Normally Functioning Kidney Allograft: A Single-Center Study

Abstract

Similar Articles

Change of Cyclosporine Absorption over the Time After Kidney Transplantation

Kidney Transplantation: Local Donor and Distant Recipient, Is It Feasible? A Retrospective Cross-Sectional Study

The Impact of Acute Rejection in Kidney Transplantation on Long-Term Allograft and Patient Outcome

Dyslipidemia in Renal Transplant Recipients Treated With Cyclosporine A

Evaluation of Cyclosporine and Tacrolimus Dose Changes During Post-transplantation Period and Their Association with Endomyocardial Biopsy Grading

Crossmark

Checking

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 2 weeks ago

Last Update: 9 hours ago