Image Credit:J Cell Mol Anesth
Outline
Congenital Prothrombin Deficiency
Authors
Abstract
Congenital prothrombin deficiency is an extremely rare hemorrhagic disorder with estimated prevalence of 1 per 2,000,000 in the general population. Since the disorder is an autosomal recessive disorder, the disorder is more frequent in areas with high rate of consanguinity. Clinical manifestations of disorder are highly variable ranging from mild bleeding episodes to severe life-threatening hemorrhages. The disorder can be diagnosed based on routine and specific tests. No specific factor II concentrate is available, but patients can receive fresh frozen plasma and prothrombin complex concentrate (PCC). Traditionally patients with prothrombin deficiency receive on-demand therapy, but secondary prophylaxis can be used for those patients with high risk of severe life-threatening bleeding. With timely diagnosis and appropriate management of disorder, the quality of life in these patients can significantly improve.? ?Keywords: Prothrombin deficiency, Clinical manifestations, Diagnosis, Treatment
Highlights
References
- 1.References are in the PDF file of the article.
Copyright
© 2018, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Burden of Congenital Factor XIII Deficiency in Iran
Dorgalaleh A. Burden of Congenital Factor XIII Deficiency in Iran. J Cell Mol Anesth. 2017;2(3):e149544. doi: https://doi.org/10.22037/jcma.v2i3.16263
Bleeding Episodes Among Patients with Congenital Fibrinogen Disorders, a Study On 12 New Iranian Patients
Naderi M, Rahamani P, Alizadeh S, Razavi H, Dorgalaleh A. Bleeding Episodes Among Patients with Congenital Fibrinogen Disorders, a Study On 12 New Iranian Patients. J Cell Mol Anesth. 2018;3(1):e150274. doi: https://doi.org/10.22037/jcma.v3i1.19754
Coagulation Factor VII: Genetic, Molecular, and Clinical Characteristics
Mashayekhi A, Ghasemi E. Coagulation Factor VII: Genetic, Molecular, and Clinical Characteristics. J Adv Immunopharmacol. 2022;2(1):e128397. doi: https://doi.org/10.5812/tms-128397
Factor XIII Deficiency, Review of the Literature and Report of a Case
Vahid Golpayegani M, Behnia H, Akhgar Araghi M, Ansari G. Factor XIII Deficiency, Review of the Literature and Report of a Case. J Compr Ped. 2016;7(4):e30303. doi: https://doi.org/10.17795/compreped-30303
Laboratory Diagnosis of Congenital Factor V Deficiency, Routine, Specific Coagulation Tests with Molecular Methods
Tabibian S, Kazemi A, Dorgalaleh A. Laboratory Diagnosis of Congenital Factor V Deficiency, Routine, Specific Coagulation Tests with Molecular Methods. J Cell Mol Anesth. 2016;1(2):e149507. doi: https://doi.org/10.22037/jcma.v1i2.10790
- Scopus by DOI: 2
Last Update: 1 month ago
- Scopus by Title: 2
Last Update: 1 month ago
- Scopus by Title (Ref): 0
Last Update: 1 month ago
- CrossRef: 0
Last Update: 6 days ago
- OpenAlex: 2
Last Update: 9 hours ago
- OpenCitations: 1
Last Update: 4 days ago