Online learning or distance learning, is an online learning activity in which students communicate with instructors and other students at an appropriate time, which does not depend on their physical location (
1). Payame Noor University in Iran established distance education methods in 1988 to address some of the shortcomings of traditional education, including time and place restrictions (
2).
There is a global issue called coronavirus disease 2019 (COVID-19) that needs to be addressed (
3). A first patient with COVID-19 was observed in Qom, Iran, on February 7, 2017 (
4). Since then, the government has decided to close schools and universities to keep people at home and control the disease spread (
5). With the advent of the COVID-19, the global medical education was disrupted. Globally, distance education is an important solution, and electronic distance learning is the primary method for evaluating distance education (
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Computer-based assessments or online examinations involve taking exams via the intranet or web (
9). Often, medical students must undergo examinations to measure their progress toward achieving the learning outcomes of the curriculum (
10).
Assessment can be used as a tool to help students learn a way to report their progress and make teaching decisions. Effective assessment requires direct evidence of student learning (
11). Several studies have highlighted the advantages and disadvantages of online exams (
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According to previous types of research, E-exam has plenty of advantages for students (
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13). A transparent and effective exam preparation system, flexibility (to time and place), frequent online quizzes, the ability to solve practice tests, less errors made by students when filling out answer bubbles, instant results, the ability to receive feedback on the exam result, and a higher degree of objectivity are among these advantages (
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14). Evaluating medical students is one of the essential aspects of curriculum development in the virtual learning. The COVID-19 pandemic has created new challenges for teachers, and virtual evaluation and grading policies are one of these challenges (
17). Ensuring medical students’ safety and timely evaluation is essential during this pandemic crisis. Medical sciences universities need to invest in individualized learning for competency-based education and technologies for assessing students' clinical skills (
18). As a result of COVID-19, universities have had to make rapid changes to offer online classes and decide whether to conduct high-risk online assessments. Additionally, students' concerns about academic progress and exams during online education increased (
19). Online assessment improves teaching and learning process both in managing distance education, increasing class size and staff workload, and teaching (to provide continuous feedback to students and staff on progress towards learning objectives), which creates challenges for the academic integrity and equality of students (
20). Low-income and lower-middle-income countries have problems with e-learning due to infrastructure challenges, resource shortages, and communication and social barriers. A recent review of the transition to e-learning in pharmacy schools in Africa found several barriers related to poor access in rural areas, high internet data costs, poor infrastructure in many places, and digital divides, both at the country and between individuals (
21).
Most universities have expressed concerns about the quality of online resources produced during the pandemic due to time constraints. For example, faculty members lack motivation and have difficulty focusing on students. Therefore, some students prefer face-to-face teaching, and many teachers are not adequately prepared (
22). Physiology is one of the most difficult courses for a medical student to learn because of requiring a thinking ability (
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