Logo
homeHome
toggle_offCompany ProfilegroupsBoards & Staffsworkspace_premiumMemberships & PartnersschoolAcademy of Journalismperson_addCareerslinkBlog(EN)emailContact Us
list_altOur JournalslightbulbInstruction for AuthorsbookmarkBrieflands PolicieshandshakePublish My Researchplay_circleJournal Management Systemcredit_cardArticle Processing Chargeszoom_inOpen Peer ReviewimagePublishing Services
menu_bookPublish My Book

IJ Radiology

An Innovative Journal in the Field of Radiology

homeHome
play_arrowCurrent IssuelistAll Issuesformat_indent_increaseIn Presscheck_circleAccepted ManuscriptssearchSearch
helpInstructions
bookmarkJournal InformationgroupsEditors and BoardsshareIndexing and Listing Sourcesshow_chartJournal Metricszoom_inOpen Peer Review (OPR)balancePublication Ethics and Malpractice Statementassignment_indReviewer and AE Registration FormemailSupportphoneContact Us
format_list_bulletedAPC
Authors GuideSubmit Manuscript

Outlines

https://doi.org/10.5812/iranjradiol.21289

Accurate Quantification of Metabolite Ratio in Osteosarcoma Employing Clinical Magnetic Resonance Spectroscopy at 3T; A Comparative Study With Normal Tissue

Author(s):
Shaghayegh Karimi AlavijehShaghayegh Karimi Alavijeh1, Mohammadali OghabianMohammadali Oghabian2, Hamidreza Saligheh RadHamidreza Saligheh Rad2,*
1Institute for Advanced Medical Technologies (IAMT)
2Tehran University of Medical Sciences, Tehran, IR Iran
IJ Radiology:Vol. 11, issue 30th Iranian Congress of Radiology; e21289
Published online:Feb 28, 2014
Article type:Research Article
How to Cite:Karimi Alavijeh S, Oghabian M, Saligheh Rad H. Accurate Quantification of Metabolite Ratio in Osteosarcoma Employing Clinical Magnetic Resonance Spectroscopy at 3T; A Comparative Study With Normal Tissue. I J Radiol. 2014;11(30th Iranian Congress of Radiology):e21289. doi: https://doi.org/10.5812/iranjradiol.21289

Abstract

Background:

Proton magnetic resonance spectroscopy imaging (1H-MRSI) has recently attracted attention in musculoskeletal applications in general, and in osteosarcoma in particular. Acquired spectra in the MRSI procedure are usually corrupted due to low signal-to-noise ratio (SNR), as well as baseline and residual water contaminations, leading to quantification errors and; therefore, misinterpretation of the ratios calculated by the clinical scanners software.

Objectives:

The aim of this study is accurate quantification of Choline-to-Creatine (Cho/Cr) ratio elevating in osteosarcoma.

Patients and Methods:

Cho/Cr were obtained in 10 patients and 10 healthy volunteers at 3T (Siemens Tim-Trio) by MRSI (PRESS, TR/TE: 2500/135 ms) using a phase-array coil with water-suppression. An extra single voxel spectroscopy (SVS) without water-suppression was acquired to provide phase information for further Eddy-current correction (ECC). Multi-stage preprocessing was applied as follows: ECC, SNR-enhancement and water-removal. Subtract-QUEST-MRSI as a time-domain technique was employed to accurately quantify the metabolite ratios and to estimate the baseline. An optimal database for subtract-QUEST was achieved based on multiple trials evaluated by acceptable peak fitting and Cramer-Rao-Bound (CRB) including Alanine, Cho, Cr, Lactate, Lipid and water. Lipids at frequencies of 0.94 and 1.33 ppm were combined to increase accuracy of the Lipid estimation.

Results:

The average values of Cho/Cr for 10 patients and 10 volunteers were 0.448 + 0.055 and 0.324 + 0.030, respectively, and the meaningful change of 35% (P < 0.0001) between the two groups. Reliability of the quantitative results was estimated by employing CRB which was about 93.6% among the 10 volunteers.

Conclusions:

In this study, we managed to observe meaningful changes in the Cho/Cr ratio in osteosarcoma lesions versus the control group employing 1H-MRSI. The best database for subtract-QUEST-MRSI was optimized in osteosarcoma. Reliability of the quantitative results was about 93.6% among the 10 volunteers.

Full Text

Full text is available in PDF
Import into EndNoteImport into BibTex
Crossmark
Crossmark
Checking
Share on
Comments
Number of Comments:0
Cited by
Metrics
Get Permission (article level)

Purchasing Reprints

  • Copyright Clearance Center (CCC) handles bulk orders for article reprints for Brieflands. To place an order for reprints, please click here (   https://www.copyright.com/landing/reprintsinquiryform/ ). Clicking this link will bring you to a CCC request form where you can provide the details of your order. Once complete, please click the ‘Submit Request’ button and CCC’s Reprints Services team will generate a quote for your review.
Search Relations

Author(s):

Related Articles

Related Article in PubMed

Related Article in Google Scholar

Create Citation Alert via Google Reader