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Iranian Journal of Pharmaceutical Research

e-ISSN 1726-6890
p-ISSN 1735-0328
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Volume 20, Issue 2

40 articles2021-04-30Vol. 20Issue 2XML
30
Apr
2021
Current Models for Predicting Drug-induced Cholestasis: The Role of Hepatobiliary Transport System
Review Article_imported

Current Models for Predicting Drug-induced Cholestasis: The Role of Hepatobiliary Transport System

Farahnaz Jazaeri,
Mohammad Sheibani,
Sadaf Nezamoleslami,
Leila Moezi,
Ahmad-Reza Dehpour*
PDFFinal Published
30
Apr
2021
Molecular Insights of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole as CRF-1 Receptor Antagonists: Combined QSAR, Glide Docking, Molecular Dynamics, and In-silico ADME Studies
Original Article

Molecular Insights of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazole as CRF-1 Receptor Antagonists: Combined QSAR, Glide Docking, Molecular Dynamics, and In-silico ADME Studies

Sunil Kumar,
Neeraj Kumar,
Chandra Shekhar Sharma,
Shashank Shekher Mishra*
PDFFinal Published
30
Apr
2021
The Effects of Spironolactone in Preventing Bile Duct Ligation-induced Hepatitis in A Rat Model
Original Article

The Effects of Spironolactone in Preventing Bile Duct Ligation-induced Hepatitis in A Rat Model

Ahmet Özer Şehirli*,
Azime Kökeş,
Ayliz Velioğlu-Öğünç,
Şermin Tetik,
Naziye Özkan,
Şule Çetinel
,et al.
PDFFinal Published
30
Apr
2021
TRAIL Conjugated Silver Nanoparticle Synthesis, Characterization and Therapeutic Effects on HT-29 Colon Cancer Cells
Original Article

TRAIL Conjugated Silver Nanoparticle Synthesis, Characterization and Therapeutic Effects on HT-29 Colon Cancer Cells

Fatih Birtekocak,
Gulen Melike Demirbolat,
Ozge Cevik*
PDFFinal Published
30
Apr
2021
Synergistic Cotreatment Potential of Soursop (Annona muricata L.) Leaves Extract with Doxorubicin on 4T1 Cells with Antisenescence and Anti-reactive-oxygen-species Properties
Original Article

Synergistic Cotreatment Potential of Soursop (Annona muricata L.) Leaves Extract with Doxorubicin on 4T1 Cells with Antisenescence and Anti-reactive-oxygen-species Properties

Irfani Aura Salsabila,
Nadzifa Nugraheni,
Faradiba Nur Ahlina,
Sari Haryanti,
Edy Meiyanto*
PDFFinal Published
30
Apr
2021
Simple Determination of p-Cresol in Plasma Samples Using Fluorescence Spectroscopy Technique
Original Article

Simple Determination of p-Cresol in Plasma Samples Using Fluorescence Spectroscopy Technique

Milad Moradi,
Jafar Soleymani*,
Hamid Tayebi-Khosroshahi,
Maryam Khoubnasabjafari,
Abolghasem Jouyban
PDFFinal Published
30
Apr
2021
Protective Effect of Crocin against Mitochondrial Damage and Memory Deficit Induced by Beta-amyloid in the Hippocampus of Rats
Original Article

Protective Effect of Crocin against Mitochondrial Damage and Memory Deficit Induced by Beta-amyloid in the Hippocampus of Rats

Bahareh Sadat Yousefsani,
Soghra Mehri,
Jalal Pourahmad*,
Hossein Hosseinzadeh*
PDFFinal Published
30
Apr
2021
Enhanced Neural Differentiation of Epidermal Neural Crest Stem Cell by Synergistic Effect of Lithium carbonate and Crocin on BDNF and GDNF Expression as Neurotrophic Factors
Original Article

Enhanced Neural Differentiation of Epidermal Neural Crest Stem Cell by Synergistic Effect of Lithium carbonate and Crocin on BDNF and GDNF Expression as Neurotrophic Factors

Shirin Ahmadi,
Mohammad Nabiuni*,
Mohammad Tahmaseb,
Elaheh Amini
PDFFinal Published
30
Apr
2021
Pharmacological Properties of Allium cepa, Preclinical and Clinical Evidences; A Review
Review Article_imported

Pharmacological Properties of Allium cepa, Preclinical and Clinical Evidences; A Review

Farzaneh Kianian,
Narges Marefati,
Marzie Boskabady,
Seyyedeh Zahra Ghasemi,
Mohammad Hosein Boskabady*
PDFFinal Published
30
Apr
2021
Protective Effect of Cinnamaldehyde on METH-induced Neurotoxicity in PC12 Cells via Inhibition of Apoptotic Response and Oxidative Stress
Original Article

Protective Effect of Cinnamaldehyde on METH-induced Neurotoxicity in PC12 Cells via Inhibition of Apoptotic Response and Oxidative Stress

Roghayeh Rashidi,
Seyed Adel Moallem,
Mohammad Moshiri,
Farzin Hadizadeh,
Leila Etemad*
PDFFinal Published
30
Apr
2021
Design, Synthesis, and Anticancer Activity Evaluation of Hybrids of Azoles and Barbituric Acids
Original Article

Design, Synthesis, and Anticancer Activity Evaluation of Hybrids of Azoles and Barbituric Acids

Hong-Juan Liu,
Xing Huang,
Qing-Kun Shen,
Hao Deng,
Zhiyong Li*,
Zhe-Shan Quan*
PDFFinal Published
30
Apr
2021
Protective Effect of Crocin on Malathion-induced Cardiotoxicity in Rats: A Biochemical, Histopathological and Proteomics Study
Original Article

Protective Effect of Crocin on Malathion-induced Cardiotoxicity in Rats: A Biochemical, Histopathological and Proteomics Study

Soudabeh Balarastaghi,
Rezvan Yazdian-Robati,
Faezeh Vahdati Hasani,
Hossein Hosseinzadeh,
Khalil Abnous,
Mohsen Imenshahidi
,et al.
PDFFinal Published
30
Apr
2021
Multilayer Alginate Microcapsules For Live Cell Microencapsulation; Is There Any Preference For Selecting Cationic Polymers?
Review Article_imported

Multilayer Alginate Microcapsules For Live Cell Microencapsulation; Is There Any Preference For Selecting Cationic Polymers?

Fariba Hajifathaliha,
Arash Mahboubi*,
Noushin Bolourchian,
Elham Mohit,
Leila Nematollahi*
PDFFinal Published
30
Apr
2021
Improvement of Drug Delivery Properties of Risperidone via Preparation of Fast Dissolution Tablet Containing Nanostructured Microparticles
Original Article

Improvement of Drug Delivery Properties of Risperidone via Preparation of Fast Dissolution Tablet Containing Nanostructured Microparticles

Motahareh Salarvand,
Vahid Ramezani*,
Fatemeh Salarvand,
Zeinab Aref Darabi,
Maryam Akrami
PDFFinal Published
30
Apr
2021
Efficacy and Safety of Melatonin as an Adjunctive Therapy on Clinical, Biochemical, and Quality of Life in Patients with Ulcerative Colitis
Original Article

Efficacy and Safety of Melatonin as an Adjunctive Therapy on Clinical, Biochemical, and Quality of Life in Patients with Ulcerative Colitis

Shabnam Shahrokh,
Roja Qobadighadikolaei,
Mohammad Abbasinazari,
Mehrdad Haghazali,
Hamid Asadzadeh Aghdaei,
Saeed Abdi
,et al.
PDFFinal Published
30
Apr
2021
Synthesis, Kinetics, Binding Conformations and Structure-activity Relationship of Potent Tyrosinase Inhibitors: Aralkylated 2-aminothiazole-ethyltriazole Hybrids
Original Article

Synthesis, Kinetics, Binding Conformations and Structure-activity Relationship of Potent Tyrosinase Inhibitors: Aralkylated 2-aminothiazole-ethyltriazole Hybrids

Abdul Rehman Sadiq Butt,
Muhammad Athar Abbasi*,
Aziz-ur- Rehman,
Sabahat Zahra Siddiqui,
Hussain Raza,
Mubashir Hassan
,et al.
PDFFinal Published
30
Apr
2021
Controllable Synthesis of Polymeric Micelles by Microfluidic Platforms for Biomedical Applications: A Systematic Review
Review Article_imported

Controllable Synthesis of Polymeric Micelles by Microfluidic Platforms for Biomedical Applications: A Systematic Review

Mahnaz Ahmadi,
Saeed Siavashy,
Seyed Mohammad Ayyoubzadeh,
Rustem Kecili,
Fatemeh Ghorbani-Bidkorbeh*
PDFFinal Published
30
Apr
2021
Evaluation of Cytotoxic Potentials of Novel Synthesized Chalconeferrocenyl Derivative against Melanoma and Normal Fibroblast and Its Anticancer Effect through Mitochondrial Pathway
Original Article

Evaluation of Cytotoxic Potentials of Novel Synthesized Chalconeferrocenyl Derivative against Melanoma and Normal Fibroblast and Its Anticancer Effect through Mitochondrial Pathway

Ahmad Salimi,
Mozhgan Ghasempour,
Shabnam Farzaneh,
Farzad Khodaparast,
Parvaneh Naserzadeh,
Afshin Zarghi*
,et al.
PDFFinal Published
30
Apr
2021
In-vitro Chemopreventive Potential of a Chromone from Bomarea setacea (ALSTROEMERIACEAE) against Colorectal Cancer
Original Article

In-vitro Chemopreventive Potential of a Chromone from Bomarea setacea (ALSTROEMERIACEAE) against Colorectal Cancer

Angie Herrera-R,
Gustavo Moreno,
Pedronel Araque,
Isabel Vásquez,
Elizabeth Naranjo,
Fernando Alzate
,et al.
PDFFinal Published
30
Apr
2021
A Review of the Phytochemistry and Antimicrobial Properties of Origanum vulgare L. and Subspecies
Review Article_imported

A Review of the Phytochemistry and Antimicrobial Properties of Origanum vulgare L. and Subspecies

Saba Soltani,
Abolfazl Shakeri,
Mehrdad Iranshahi,
Motahareh Boozari*
PDFFinal Published
30
Apr
2021
In-vitro Effect of Imipenem, Fosfomycin, Colistin, and Gentamicin Combination against Carbapenem-resistant and Biofilm-forming Pseudomonas aeruginosa Isolated from Burn Patients
Original Article

In-vitro Effect of Imipenem, Fosfomycin, Colistin, and Gentamicin Combination against Carbapenem-resistant and Biofilm-forming Pseudomonas aeruginosa Isolated from Burn Patients

Mohammad Yousef Memar,
Khosro Adibkia,
Safar Farajnia,
Hossein Samadi Kafil,
Younes Khalili,
Robab Azargun
,et al.
PDFFinal Published
30
Apr
2021
Plasma Concentration of Taurine Changes following Acetaminophen Overdose in Male Patients during Hospitalization
Original Article

Plasma Concentration of Taurine Changes following Acetaminophen Overdose in Male Patients during Hospitalization

Mohammadreza Sattari,
Ali Ostadi,
Shokoufeh Hassani,
Zeynab Mazloumi,
Hamid Noshad,
Kayvan Mirnia
,et al.
PDFFinal Published
30
Apr
2021
Synthesis and Antiplatelet Activity Evaluation of a Group of Novel Ethyl Acetoacetate Phenylhydrazone Derivatives
Original Article

Synthesis and Antiplatelet Activity Evaluation of a Group of Novel Ethyl Acetoacetate Phenylhydrazone Derivatives

Sarveen Farhady,
Farzad Kobarfard,
Lotfollah Saghaei,
Mahboubeh Rostami*
PDFFinal Published
30
Apr
2021
Inhibition of HMGB1 Might Enhance the Protective Effect of Taxifolin in Cardiomyocytes via PI3K/AKT Signaling Pathway
Original Article

Inhibition of HMGB1 Might Enhance the Protective Effect of Taxifolin in Cardiomyocytes via PI3K/AKT Signaling Pathway

Erjun Feng,
Jian Wang,
Xinwei Wang,
Zhenguo Wang,
Xiaochu Chen,
Xu Zhu*
,et al.
PDFFinal Published
30
Apr
2021
HIV-1 Reverse Transcriptase/Integrase Dual Inhibitors: A Review of Recent Advances and Structure-activity Relationship Studies
Review Article_imported

HIV-1 Reverse Transcriptase/Integrase Dual Inhibitors: A Review of Recent Advances and Structure-activity Relationship Studies

Mohammad Mahboubi-Rabbani,
Maryam Abbasi,
Zahra Hajimahdi,
Afshin Zarghi*
PDFFinal Published
30
Apr
2021
Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways
Review Article_imported

Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways

Madiha Khalid,
Mahshid Hodjat,
Mohammad Abdollahi*
PDFFinal Published
30
Apr
2021
Effect of Adjunctive Topical Liposomal Azithromycin on Systemic Azithromycin on Old World Cutaneous Leishmaniasis: A Pilot Clinical Study
Original Article

Effect of Adjunctive Topical Liposomal Azithromycin on Systemic Azithromycin on Old World Cutaneous Leishmaniasis: A Pilot Clinical Study

Bahareh Abtahi-Naeini,
Sajjad Hadian,
Fatemeh Sokhanvari,
Amirali Hariri,
Jaleh Varshosaz,
Zabihollah Shahmoradi
,et al.
PDFFinal Published
30
Apr
2021
Isolation and Structural Elucidation of Novel Antidiabetic Compounds from Leaves of Momordica balsamina Linn and Leptadenia hastata (Pers) Decne
Original Article

Isolation and Structural Elucidation of Novel Antidiabetic Compounds from Leaves of Momordica balsamina Linn and Leptadenia hastata (Pers) Decne

Nafisatu Kabir*,
Ismail A Umar,
Habila A Dama,
Dorcas B James,
Hajiya M Inuwa
PDFFinal Published
30
Apr
2021
Utilization, Cost, and Affordability of Antihypertensive Therapy in Bulgaria
Original Article

Utilization, Cost, and Affordability of Antihypertensive Therapy in Bulgaria

Zornitsa Mitkova*,
Guenka Petrova
PDFFinal Published
30
Apr
2021
6-Methoxylated Flavonoids: Jacein, and 3-demethyljacein from Centaurea schmidii with Their Endoplasmic Reticulum Stress and Apoptotic Cell Death in Breast Cancer Cells Along with In-silico Analysis
Original Article

6-Methoxylated Flavonoids: Jacein, and 3-demethyljacein from Centaurea schmidii with Their Endoplasmic Reticulum Stress and Apoptotic Cell Death in Breast Cancer Cells Along with In-silico Analysis

Mahmoud Aghaei,
Mahmoud Mirzaei,
Mustafa Ghanadian*,
Moslem Fallah,
Roodabeh Mahboodi
PDFFinal Published
30
Apr
2021
Simultaneous Analysis of 10 Priority PAHs in Iranian Sangak Bread Samples by Developing a GC-MS Method
Original Article

Simultaneous Analysis of 10 Priority PAHs in Iranian Sangak Bread Samples by Developing a GC-MS Method

Farzad Peiravian,
Attaollah Shakoori,
Vahideh Moradi,
Jamshid Salamzadeh*,
Arash Mahboubi
PDFFinal Published
30
Apr
2021
Efficacy and Safety of Different Dosage of Recombinant Tissue-type Plasminogen Activator (rt-PA) in the Treatment of Acute Pulmonary Embolism: A Systematic Review and Meta-analysis
Review Article_imported

Efficacy and Safety of Different Dosage of Recombinant Tissue-type Plasminogen Activator (rt-PA) in the Treatment of Acute Pulmonary Embolism: A Systematic Review and Meta-analysis

Shahideh Amini,
Hooman Bakhshandeh,
Reza Mosaed,
Hamidreza Abtahi,
Kourosh Sadeghi,
Mojtaba Mojtahedzadeh*
PDFFinal Published
30
Apr
2021
How Much Iranian Parents Know of and How Well They Practice Regarding Antibiotics?
Original Article

How Much Iranian Parents Know of and How Well They Practice Regarding Antibiotics?

Zahra Sharif,
Fateme Babaei,
Nazila Yousefi,
Yasaman Alavian,
Farzad Peiravian
PDFFinal Published
30
Apr
2021
A Pilot Randomized, Clinical Trial of the Anti-pruritus Effect of Melatonin in Patients with Chronic Liver Disease
Original Article

A Pilot Randomized, Clinical Trial of the Anti-pruritus Effect of Melatonin in Patients with Chronic Liver Disease

Ayda Esmaeili,
Mohssen Nassiri Toosi,
Mohammad Taher,
Shahin Merat,
Jaleh Bayani,
Zahra fruzan. Karimian
,et al.
PDFFinal Published
30
Apr
2021
Minimum Data Set for a Poisoning Registry: A Systematic Review
Review Article_imported

Minimum Data Set for a Poisoning Registry: A Systematic Review

Azam Sabahi,
Farkhondeh Asadi*,
Shahin Shadnia,
Reza Rabiei,
Azamossadat Hosseini
PDFFinal Published
22
Aug
2021
Quorum Sensing Inhibitors: Curbing Pathogenic Infections through Inhibition of Bacterial Communication
Review Article

Quorum Sensing Inhibitors: Curbing Pathogenic Infections through Inhibition of Bacterial Communication

Shaminder Singh*,
Sonam Bhatia
PDFFinal Published
30
Apr
2021
Evaluation of the Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction through Aβ and Cytokines Analysis
Original Article

Evaluation of the Effect of Dexmedetomidine on Postoperative Cognitive Dysfunction through Aβ and Cytokines Analysis

Zhi Li,
Shanglong Yao,
Minghua Cheng*,
Jianyan Chen*
PDFFinal Published
30
Apr
2021
Studying the Expression Efficiencies of Human Clotting Factor IX Analogs, Rationally-designed for Hyper-glycosylation
Original Article

Studying the Expression Efficiencies of Human Clotting Factor IX Analogs, Rationally-designed for Hyper-glycosylation

Fahimeh Ghasemi,
M.Reza Khorramizadeh*,
Ali Asghar Karkhane,
Alireza Zomorodipour*
PDFFinal Published
30
Apr
2021
Synthesis, Antimicrobial Activity, and Molecular Docking Studies of Aminoguanidine Derivatives Containing an Acylhydrazone Moiety
Original Article

Synthesis, Antimicrobial Activity, and Molecular Docking Studies of Aminoguanidine Derivatives Containing an Acylhydrazone Moiety

Xiaodong Yao,
Hongmei Hu,
Shiben Wang,
Wenhao Zhao,
Mingxia Song,
Qiugui Zhou*
PDFFinal Published
30
Apr
2021
Semi-Synthesis of New 1,2,3-Triazole Derivatives of 9-Bromonoscapine and their Anticancer Activities
Original Article

Semi-Synthesis of New 1,2,3-Triazole Derivatives of 9-Bromonoscapine and their Anticancer Activities

Zahra Hasanpour,
Peyman Salehi*,
Morteza Bararjanian,
Mohammad-Ali Esmaeili,
Mostafa Alilou,
Maryam Mohebbi
PDFFinal Published